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Burkholderia cenocepacia requires complete lipopolysaccharide to resist bacterial killing agents
DownloadSpring 2023
Antibiotic-resistant infections are a growing concern, if this issue is not addressed by the year 2050 these infections will cause ~10 million deaths per year. Traditional antibiotics targeting essential life processes have demonstrated a rapid rate of resistance development. Modern antibiotics...
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Fall 2021
The race towards uncovering and developing novel antibiotics requires a multipronged, interdisciplinary approach. Highlighted in this thesis are biochemical and structural studies on peptides, small naturally occurring molecules that have innate bioactivities, such as antimicrobial...
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MULTIDRUG-RESISTANT PSEUDOMONAS AERUGINOSA – A PROBLEM IN HOT TUBS AND WHIRLPOOLS IN CANADA
DownloadFall 2022
Objectives: Pseudomonas aeruginosa is one of the most problematic opportunistic pathogens. It is resistant to many currently used antibiotics, making it difficult to treat, and resistance may transfer to other P. aeruginosa strains. The organism can acquire resistance through horizontal gene...