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Skip to Search Results- 1Ahmed, Kazi Tanveer
- 1Ali, Declam
- 1Aroonassala Patten, Shunmoogum
- 1Attia, Karen
- 1Brewster, Daniel L
- 1Cerdá-Reverter, J.M.
- 31Graduate and Postdoctoral Studies (GPS), Faculty of
- 31Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
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- 1WISEST Summer Research Program/WISEST Research Posters
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Retinoic acid prevents alteration of neuronal morphology and locomotion of zebrafish embryos induced by ethanol exposure during gastrulation
DownloadFall 2018
Ethanol (EtOH) exposure during development has been shown to lead to deficits in fine and gross motor control. In this study I used zebrafish embryos in the gastrulation stage to determine the developmental effects of a brief, 5-hour exposure to EtOH. I treated fertilized zebrafish eggs from 5.25...
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Fall 2015
Calcium/calmodulin dependent protein kinase 2 (CaMKII) is a multifunctional serine/threonine kinase that is highly abundant in the central nervous system. It plays important roles in many neuronal functions, including neurite extension and maturation, activity-dependent synaptic plasticity and...
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Fall 2023
Phosphoinositides (PIs) are membrane lipids that function as signaling molecules. PIs undergo phosphorylation and dephosphorylation at various positions to produce the seven known PI molecules. PIKfyve is a phosphoinositide kinase that produces phosphoinositide-3,5- bisphosphate (PI(3,5)P2) and...
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The Expression of Transmembrane AMPA Receptor Regulatory Proteins (TARPs) in Developing Zebrafish (Danio rerio)
DownloadFall 2013
In embryonic vertebrates, newly-formed synapses are quiet until they are unsilenced through a process that resembles synaptic plasticity but remains mechanistically unclear. I used gene expression to determine if Transmembrane AMPA Receptor Regulatory Proteins (TARPs), AMPA receptor auxiliary...
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The Role of Forkhead Box Transcription Factors in Zebrafish Ocular Development and the Superior Ocular Fissure
DownloadFall 2014
Ocular development is a tightly orchestrated process that is dependent upon precise environmental and genetic factors. Disruption of this can result in microphthalmia, anophthalmia and coloboma (MAC), which is a spectrum of congenital ocular disease with lifelong consequences affecting sight. In...
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The roles of Pbx and Meis TALE-class homeodomain transcription factors in vertebrate neural patterning
DownloadFall 2010
One of the major goals of developmental biology is to understand how specialized groups of cells arise from an initially unspecified cell population. The vertebrate hindbrain is transiently segmented along its anterior-posterior axis into lineage-restricted compartments called rhombomeres, making...
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Transcriptional regulation of the zebrafish activation-induced cytidine deaminase (AID) gene
DownloadFall 2012
Activation-induced cytidine deaminase (AID, encoded by Aicda) mediates affinity maturation of immunoglobulin genes. Early studies in mammals indicated that the transcription of Aicda was regulated by a number of transcriptional regulatory regions, including a B-cell specific enhancer in the...
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Transcriptomic analysis of zebrafish prion protein mutants supports conserved cross-species function of the cellular prion protein; and zebrafish as a model for cisplatin induced ototoxicity and transition metals as potential ligands for Tlr4ba and Tlr4bb
DownloadFall 2021
The work presented in this thesis is split between two projects. The first utilises prp1 and prp2 knockout zebrafish to investigate physiological functions of the cellular prion protein (PrPC). The second builds upon the use of zebrafish as a model for hearing loss to confirm a role of toll-like...
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Using a Zebrafish Animal Model to Identify the First Candidate Gene for Pigmentary Glaucoma
DownloadSpring 2019
Premelanosome protein (PMEL) was identified as a candidate gene for the development of pigment dispersion syndrome (PDS) and pigmentary glaucoma (PG) in humans. Mutations in PMEL were shown to cause pigment and ocular defects in several animals but there is currently no known PMEL associated...