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Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
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Fall 2019
Cilia are microtubule-based structures that project from nearly every cell in the vertebrate body. While cilia in different contexts can have either sensory or motile functions, all cilia rely upon a core set of genes. When these genes are mutated either singly or in various combinations, a...
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The Role of MAGEL2 in Ubiquitination Pathways and its Contribution to Prader-Willi and Schaaf-Yang Syndromes
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The MAGEL2 gene is implicated in two neurodevelopmental disorders: Prader-Willi syndrome (PWS) and Schaaf-Yang syndrome (SYS). PWS is characterized by intellectual disability, obesity, poor muscle tone, distinct facial features, excessive daytime sleepiness and nighttime wakening. PWS is a...
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Investigation of transcriptional and translational regulation of the Neurospora crassa alternative oxidase
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Mitochondria are organelles found in most eukaryotes and supply the cell with the majority of its energy needs in the form of ATP. Most of the proteins needed for mitochondrial function are nuclear encoded. Therefore, mitochondria communicate their functional status to the nucleus, resulting in...
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Spring 2018
Choroideremia is an X-linked monogenic inherited retinal disease. It affects males starting in their teenage years with night blindness followed by progressive vision loss starting in the peripherals and ending with total vision loss late in life. It is estimated that 1 in 50,000 individuals...
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Spring 2017
Cannabis use is a known risk factor for the development of psychotic disorders. Clinical and preclinical genetic studies provide growing evidence that genes related to dopamine signalling and neuroprotection, like COMT, are implicated in the cannabis-psychosis association. Considering the burden...
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Advanced agronomic practices to maximize feed barley (Hordeum vulgare L.) yield, quality, and standability in Alberta environments
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The grain yields of feed barley (Hordeum vulgare L.) have increased at a slower rate than the yields of other major crops in Alberta, and seeded barley acres have declined over the past 20 years. Agronomic management and cultivar specific responses to management may provide solutions to increase...
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Spring 2017
Pulses of ecdysone, a steroid hormone, play an integral role during insect development however, how these ecdysone pulses are regulated has been relatively unexplored. I have shown that the presence of nitric oxide (NO) within the larval prothoracic gland (PG), the principal source of larval...
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Fall 2017
NPAS3 encodes a transcription factor of the bHLH-PAS family, which has been robustly associated with neurodevelopmental and psychiatric disorders with intellectual disability as a common feature. NPAS3 was initially discovered as a schizophrenia-associated gene in a family with a translocation...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...