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Skip to Search Results- 3Protein prenylation
- 2Autophagy
- 1Alzheimer's disease
- 1Amyloid beta
- 1Amyloid beta peptide
- 1Cholesterol
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Spring 2014
Alzheimer’s disease (AD) is the most common form of dementia in the elderly. The major pathological features of AD are extracellular amyloid plaques, intracellular neurofibrillary tangles and neuronal loss. Amyloid beta (Aβ) peptide, the main component of the amyloid plaques, has been proposed to...
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Spring 2016
There is ample evidence that autophagy is affected in Alzheimer’s disease (AD) but the causes, the nature of the dysfunction and the mechanisms of autophagy impairment are unclear. Autophagy depends on vesicular trafficking and membrane fusion, events that rely on several protein complexes and...
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Fall 2018
Huntington’s disease (HD) is a monogenic neurodegenerative disorder characterized by progressive choreic movements, dystonia, motor incoordination, cognitive decline and behavioural changes. HD is caused by an abnormal increase in the number of CAG repeats in the exon 1 of the huntingtin (HTT)...