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Skip to Search Results- 19Prions
- 16Biomarkers
- 4Neurodegeneration
- 3Chronic wasting disease
- 2Alzheimer's Disease
- 2Apolipoprotein E
- 1Acevedo Morantes, Claudia Y
- 1Aguzzi, Adriano
- 1Bao, Hua
- 1Baral, Pravas K.
- 1Braithwaite, Shannon Lynn
- 1Cardenas, Maria Eugenia
- 29Graduate and Postdoctoral Studies (GPS), Faculty of
- 29Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Computing Science, Department of
- 1Computing Science, Department of/Technical Reports (Computing Science)
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Correlation of Subregional Hippocampal Thickness Abnormalities with Positron Emission Tomography Phosphorylated Tau Measurements in Patients with Mild Cognitive Impairment and Alzheimer's Disease
DownloadFall 2023
Alzheimer’s disease (AD) is the most common cause of dementia and is an emerging public health crisis with 150 million cases projected globally by 2050. Biomarkers are playing an emerging role in AD research - however, existing biomarkers have substantial limitations. Magnetic Resonance Imaging...
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Spring 2022
Carotid atherosclerosis is responsible for 15-25% of the nearly 8 million first-ever ischemic strokes that occur each year worldwide. This proportion has remained constant over the past three decades, thus suggesting that some patients with carotid atherosclerosis currently receive suboptimal...
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Fall 2021
Background Human Immunodeficiency Virus (HIV) is a major cause of mortality and morbidity globally. Vertical transmission is the primary mode of HIV acquisition among infants. Although successful interventions have reduced vertical transmission to less than <2.9% in low-to-middle income countries...
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Fall 2020
Neurodegenerative diseases are a rising concern worldwide. Currently 10% of people aged 65 or more are diagnosed with a neurodegenerative disease and this number is predicted to triplicate by 2050. In developed societies approximately one percent of the global gross domestic product is allocated...
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Fall 2019
Human prion diseases present as sporadic, familial, infectious, or iatrogenic forms. They include diseases such as Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), and Fatal Familial Insomnia (FFI). The wide range of phenotypic variation in human prion diseases is...
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Spring 2018
Lung cancer has the highest mortality rates of all cancers worldwide, with a 5-year survival rate less than 15%. Screening methods are in need for the high risk population, as lung cancer is asymptomatic in its early stages. Proper screening methods would allow earlier diagnosis and curative...
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Quantitative Label-Free Comparative Proteomic Analyses of Eukaryotic Tissues via Mass Spectrometry
DownloadFall 2018
In recent years, rapid advances in genomic and transcriptomic sequencing technologies have enabled the compilation of vast libraries of protein sequences and thus an explosion in bioinformatics-based fields of research. Among these is proteomics – the study of global protein abundance within a...
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Spring 2018
The presence of natural oil seeps, abandoned well sites (generally containing light oil), and high quality source rocks along the coast of western Newfoundland has refocused interest on the region as an area for potential petroleum exploration and development. Most of the oil seeps and old well...
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Cervid Prion Protein Polymorphisms Modulate the Diversity of Chronic Wasting Disease Prion Strains
DownloadSpring 2017
Chronic wasting disease (CWD) is a contagious prion disease spreading and emerging in wild and captive Cervidae species worldwide. Prion diseases are fatal neurodegenerative disorders occurring in various mammalian species including deer, elk, sheep, cattle and humans. Central to prion...
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Fall 2017
Molecular imaging techniques are important for understanding fundamental biological processes and genetic functions in organisms. Non-invasive, high-resolution, deep imaging, as well as the ability to separate molecular species, are all critical to the success of a molecular imaging technique....