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Skip to Search Results- 5Department of Physiology
- 2Centre for Neuroscience
- 2Neuroscience
- 1Department of Biological Sciences
- 1Department of Paediatrics
- 1Medical Sciences-Medical Genetics
- 2Ballanyi, Klaus (Physiology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Campbell, Shelagh (Biological Sciences)
- 1Cheung, Po-Yin (Department of Paediatrics), Co-Supervisor
- 1Dickson, Clayton (Neuroscience and Mental Health Institute, Psychology, Physiology, Anesthesiology and Pain Medicine
- 1Funk, GD (Physiology, Neuroscience)
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The Effect of Caffeine on the Neurobehavioral and Neuropathological Outcome of the Newborn Rat
DownloadSpring 2010
Caffeine is used for the treatment of apnea of prematurity. The objective of this study was to determine the long term neuropathological and neurobehavioral effects of caffeine on the immature rat brain. Newborn rats were injected with either caffeine, or normal saline from postnatal days 3 to 7,...
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Spring 2016
The hypoxic ventilatory response comprises of an initial increase in ventilation, followed by a secondary depression that can be life threatening in premature infants. During hypoxia, ATP is released in the ventrolateral medulla, where it is suggested to attenuate the secondary hypoxic...
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Postnatal development of the purinergic signaling system in the preBötzinger Complex; implications for the hypoxic ventilatory response
DownloadFall 2023
Low oxygen (hypoxia) evokes the biphasic hypoxic ventilatory response (HVR), in which carotid-body chemoreceptors trigger a rapid increase in ventilation (VE) followed by a centrally-mediated, secondary hypoxic depression of respiration (HRD) and metabolic rate (VO2) that involves adenosine. In...
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Modulation of Spontaneous Neural Network Bursting in Newborn Rat Brain Slices by Extracellular Calcium, Methylxanthines, and Opioids
DownloadFall 2012
Spontaneous neuronal bursting appears to be pivotal for brain maturation. This thesis studied such synchronized neural network oscillations in immature newborn rat hippocampus, cortex, and locus coeruleus. For this, horizontal brain slices were generated for (simultaneous) suction electrode...
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Mechanisms underlying P2Y1 receptor-mediated excitation of the inspiratory network in vitro; and NPY-induced stress resilience in vitro and in vivo
DownloadSpring 2021
The present thesis will discuss the cellular and molecular mechanisms by which neurochemical systems modulate the activity of CNS networks underlying breathing and anxiety. The thesis is divided into two parts. The first part examines the mechanisms by which the neuromodulator/neurotransmitter...
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Drosophila Mage, a component of Smc5/6 DNA response complex, confers resistance to caffeine and genotoxic stress and plays a role in the cell cycle and cell survival
DownloadFall 2014
Over 50 Melanoma-associated antigen (MAGE) genes have been identified in the human genome. They share a conserved 200 amino acid MAGE-homology domain (MHD). In yeast, the only MAGE homolog (Nse3) is a component of the Smc5/6 DNA damage response complex. In humans, MAGE proteins influence cell...
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Spring 2010
Microglia, the resident immune cells of the central nervous system (CNS), become activated in response to danger signals given out by other cells when homeostasis has been disturbed. Microglial activation is a multifaceted phenomenon that includes numerous distinct phenotypes. The type of...
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Can caffeine alter blood potassium concentration or the perception of pain and fatigue after a 1 km cycling sprint?
DownloadSpring 2013
Caffeine is used by some athletes to improve endurance performance, however, the mechanism(s) by which caffeine elicits performance improvements have been unclear. The purpose of this study was to investigate the effects of caffeine on pain perception, fatigue perception, plasma catecholamine...
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Calcium Imaging and Field Potential Analysis of Autocrine Neuromodulation in the Locus Coeruleus of Newborn Rat Brain Slices
DownloadFall 2022
The locus coeruleus (LC) is a small brainstem nucleus that controls diverse behaviours and brain functions via release of noradrenaline (NA) in the neonatal time period. There is increasing evidence of complexity in this neuron-astrocyte ‘neural’ network that remains mostly unexplored in...
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Spring 2015
Besides being the most popular drug in the world, caffeine is an attractive tool used in research to help us answer fascinating scientific questions, because caffeine impinges on a number of molecular pathways. In my research, I used caffeine to study DNA repair pathways and insect xenobiotic...