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Fall 2024

May, Julia F.

The stochastic diversification of the T cell receptor (TCR) carries with it both the potential for recognizing virtually infinite foreign peptides, but also the potential for the erroneous recognition of self-peptides, which represents a threat of autoimmunity. During development in the thymus, T...

Fall 2019

Kelly, Rees G

T cells are a vital part of the adaptive immune system that function to eliminate foreign threats while remaining tolerant to healthy-self. During T cell development in the thymus, T cells are generated with various T cell receptor (TCR) specificities, such that they can respond to a near endless...

Fall 2016

Ellestad, Kristofor K

T lymphocytes (T cells) are powerful directors and effectors of immunity. The system of pseudo-random rearrangements of the T cell receptor (TCR) loci that underlie their ability to recognize a vast universe of molecular patterns is at once useful and dangerous, because many T cells develop TCR...

Spring 2023

Adegoke, Adeolu

Recent thymic emigrants (RTE) are newly generated T cells that have just been exported to the periphery, where they continue their maturation to become mature T cells. RTE have only undergone central tolerance in the thymus but not yet undergone peripheral tolerance. As such, it is imperative...

Spring 2011

Parkman, Julia C

The immune system must be able to mount a response against pathogens and transformed cells while remaining tolerant to healthy host tissue. A key process for ensuring this self-tolerance is the negative selection of self-reactive thymocytes. Expression of Programmed Death-1 (PD-1), a...