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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Deciphering the molecular mechanisms underlying the pathobiology of esophageal squamous cell carcinoma
DownloadFall 2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide, largely due to a high frequency of tumor invasion/metastasis, chemoresistance and recurrence. In this study, we explored from different perspectives the molecular mechanisms behind these aggressive features of...