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Delineation of Molecular Mechanisms Underlying the Pathobiology of ALK-positive Anaplastic Large-cell Lymphoma
DownloadSpring 2017
ALK-positive anaplastic large-cell lymphoma (ALK+ALCL) is a rare type non-Hodgkin lymphoma of null/T cell original, preferentially occurs in children and young adults. Approximately 85% of ALK+ALCL patients carry the gene translocation t(2;5)(p23;q35), which results in the generation of the...
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Fall 2014
The vast majority of anaplastic lymphoma kinase positive anaplastic large cell lymphoma (ALK+ALCL) tumors carry the genetic translocation t(2;5)(p23;q35), leading to production of the constitutively active fusion tyrosine kinase NPM-ALK. NPM-ALK expression and its potent transformative properties...
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Fall 2019
Forkhead Box M1 (FOXM1) is a transcription factor which belongs to the evolutionary conserved Forkhead protein family. FOXM1 has been implicated in the pathogenesis of several solid and hematologic cancers. In this study, the significance of FOXM1 in NPM-ALK-positive anaplastic large cell...
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The Role of Oncogenic Tyrosine Kinase NPM-ALK in Anaplastic Large Cell Lymphoma Pathobiology
DownloadFall 2012
Anaplastic lymphoma kinase expressing anaplastic large cell lymphoma (ALK+ALCL) is an aggressive type of T/null cell lymphoma that mainly affects children and young adults and represents up to 40% of non-Hodgkin’s lymphoma in children. These lymphomas are characterized by the abnormal chromosomal...