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Skip to Search Results- 3Mitochondria
- 112,13-DiHOME
- 1Cardiac
- 1Cytochrome P450 epoxygenase
- 1Doxorubicin-Induced Cardiotoxicity
- 1Endoplasmic/Sarcoplasmic Reticulum
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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Novel Roles of Matrix Metalloproteinase-2 in Mitochondrial and Endoplasmic/Sarcoplasmic Reticulum Dysregulation
DownloadFall 2024
Matrix metalloproteinase-2 (MMP-2) is a ubiquitous multifunctional protease that cleaves both extracellular and intracellular proteins. MMP-2 is synthesized as an inactive zymogen. It is rapidly activated inside the cell in response to oxidative stress during different cardiac pathologies such as...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...