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Skip to Search Results- 3Neupert, W.
- 2Nargang, F. E.
- 1Ahting, U.
- 1Akhnokh, Maria Kodsy
- 1BATCHU, SRI NAGARJUN
- 1Bahitham, Wesam
- 30Graduate and Postdoctoral Studies (GPS), Faculty of
- 30Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Biological Sciences, Department of
- 3Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 2Agricultural, Food and Nutritional Science, Department of
- 2Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
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Using 1H-NMR based metabolomics to investigate the pathological consequences of mitochondrial disease and human rabies infection
DownloadSpring 2012
Mitochondrial diseases encompass a wide range of clinical phenotypes. The etiology of these disorders is extremely complex; mitochondria are central to energy metabolism and dysfunction can have a profound effect on global metabolism. The original objective of this thesis was to use 1H-NMR based...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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The TOM core complex: the general protein import pore of the outer membrane of mitochondria
Download1999
Thun, C., Neupert, W., Hegerl, R., Nussberger, S., Typke, D., Ahting, U., Nargang, F. E.
Abstract: Translocation of nuclear-encoded preproteins across the outer membrane of mitochondria is mediated by the multicomponent transmembrane TOM complex. We have isolated the TOM core complex of Neurospora crassa by removing the receptors Tom70 and Tom20 from the isolated TOM holo complex by...
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The Oxa2 protein of Neurospora crassa plays a critical role in the biogenesis of cytochrome oxidase and defines a ubiquitous subbranch of the Oxa1/YidC/Alb3 protein family
Download2004
Herrmann, J.M., Nargang, F.E., Neupert, W., Funes, S.
Proteins of the Oxa1/YidC/Alb3 family mediate the insertion of proteins into membranes of mitochondria, bacteria, and chloroplasts. Here we report the identification of a second gene of the Oxa1/YidC/Alb3 family in the genome of Neurospora crassa, which we have named oxa2. Its gene product, Oxa2,...
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The Cardioprotective Role of the N-3 PUFA Metabolite 19,20-Epoxydocosapentaenoic Acid (19,20-EDP) in the Setting of Ischemia Reperfusion Injury
DownloadSpring 2022
Ischemic heart disease (IHD) is a leading cause of cardiovascular morbidity and mortality worldwide. Myocardial ischemia occurs when a coronary artery is occluded and consequently blood supply to the heart is restricted depleting it of oxygen and nutrients. Although early myocardial reperfusion,...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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Fall 2023
12,13-dihydroxy-9z-octadecenoic acid (12,13-DiHOME) is a linoleic acid-derived cardiac metabolite produced in endotoxin-induced cardiomyopathy, correlating with myocardial dysfunction, inflammation, and mitochondrial damage. The contribution of 12,13-DiHOME to inflammation in the heart is...
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Spring 2016
Mitochondria are at the center of cardiac health and disease. These vital organelles provide most of the energy to the contractile apparatus and play a strategic role in cardiomyocyte survival during cellular stress. Cardiovascular diseases and many aging related diseases are often associated...