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A Reversible Metabolic Stress-Sensitive Regulation of Collapsin Response Mediator Protein 2A Orchestrates Cytoskeletal Remodeling and EMT, Increasing Metastatic Potential in Cancer
DownloadFall 2021
Cancer represents the second leading cause of death globally only after heart disease and is responsible for about 10 million deaths per year with a significant economic impact (WHO facts). Moreover, its prevalence is projected to increase over the following decades. Among all cancers, breast,...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Spring 2020
Cardiovascular (CV) diseases (CVD) have been the leading cause of death globally for decades. Effective prevention, treatment and management programs are needed to attenuate the negative impact of CVDs. Despite the efforts to provide the required evidence for these programs, the majority of...
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Severe cholestasis during the first year post-transplant predicts primary sclerosing cholangitis recurrence
DownloadFall 2021
Background Primary Sclerosing Cholangitis (PSC) is a chronic cholestatic disease of unknown etiology, whose only definitive management is liver transplantation. One of the dilemmas that PSC patients face is the recurrence of the disease in the graft, which may shorten the organ’s life expectancy...