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Fall 2017

Silbernagel, Patricia del Rocio

Objective: We sought to determine if azithromycin, a macrolide antibiotic with anti-inflammatory(1,2), antibacterial(3) and potential antiviral(4) properties, added to routine therapy of wheezy pre-school children would resolve respiratory symptoms more rapidly, and protect against symptom...

Spring 2019

Carter, Laura

Background: Children are at high risk for malnutrition during hospital admission. Over half of children admitted to hospital will exhibit signs of nutrition deterioration such as weight loss. Screening for malnutrition is a critical step in the nutrition care process, however there is currently a...

Fall 2023

Persad, Kaya L

Proliferating cells, such as neonatal cardiomyocytes, have a high Warburg effect, which is a metabolic state in which there is high rates of glycolysis uncoupled from glucose oxidation under aerobic conditions. The Warburg effect is typically seen in cancerous cells and actively proliferating...

Fall 2021

Cyrkot, Samantha

Background: Celiac disease (CD) is an autoimmune disease that results in inflammation and damage to the small intestine when gluten, a protein found in wheat, rye or barley is consumed. The only treatment for CD is lifelong adherence to the gluten-free diet (GFD). However, dietary intake can be...

Fall 2022

Bedard, Katherine

Background and Rationale: Chronological age does not always accurately reflect “biological age”, or the extent of physiological reserve an individual possesses to endure stressors. The concept of physiological reserve is best represented by frailty; a multifaceted syndrome or state that...

Spring 2011

Duffy, Terri-Lynn

Intestinal enteropathy is a prevalent yet neglected aspect of child malnutrition involving chronic exposure to intestinal pathogens such as Giardia intestinalis. Gangliosides have therapeutic potential for the treatment of giardiasis and intestinal enteropathy. The objectives of the thesis were...

Fall 2022

Halpin, Anne M

Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...

Spring 2021

Conway, Jennifer

Mechanical circulatory support has become a therapeutic option for children with advanced heart failure. This type of support is often used to bridge patients to heart transplantation with approximately a third of all patients listed for transplant requiring some form of mechanical support. While...

Fall 2020

Afhami, Shima

Obesity is a complex multifactorial disease that has a large array of direct (e.g. altered metabolic and inflammatory profile) and indirect (e.g. mental health concerns etc.) consequences on health and is associated with increased morbidity and mortality. Prader-Willi Syndrome (PWS) is the most...