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Fall 2009
MUC1, a protein of epithelial and carcinoma cells, has recently been shown on activated T cells where it inhibits CD3-stimulated proliferation. Two immunoregulatory domains similar to ITAM and ITIMs are present on its cytoplasmic tail, suggesting that MUC1 can act as both a costimulatory and...
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Structural aspects of the interaction of the cytoplasmic domain of Mucin-1 (MUC1) with the SH3 domain of Src Kinase
DownloadFall 2011
Marasinghe Arachchige, Bodhi Nirosha
Abstract Breast cancer is the second most frequent cause of cancer deaths in Canadian women with death resulting from the spread of cancer cells or metastasis to distal organs. Our laboratory was the first to show that MUC1, a type-1 transmembrane glycoprotein highly overexpressed in breast...