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Skip to Search Results- 2Graduate and Postdoctoral Studies (GPS), Faculty of
- 2Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Concordia University of Edmonton
- 1Concordia University of Edmonton/Independent Research Reports in Undergraduate Biology and Environmental Science (Concordia University of Edmonton)
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Investigation of the Prader-Willi syndrome protein MAGEL2 in the regulation of Forkhead box transcription factor FOXO1
DownloadSpring 2013
Prader-Willi syndrome (PWS), a genetic disorder resulting from the loss of expression of multiple genes including MAGEL2, is characterized by hyperphagia and childhood-onset obesity. These symptoms point to dysfunction in the regulation of energy homeostasis. Magel2 is highly expressed in the...
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2016-11-04
Background: Prader-Willi syndrome (PWS) is a multigene disorder commonly associated with hyperphagia and obesity. Children with PWS have increased fat mass and decreased lean mass before the onset of hyperphagia and obesity. Severe hypotonia and reduced muscle strength are typically present in...
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The Role of MAGEL2 in Ubiquitination Pathways and its Contribution to Prader-Willi and Schaaf-Yang Syndromes
DownloadFall 2019
The MAGEL2 gene is implicated in two neurodevelopmental disorders: Prader-Willi syndrome (PWS) and Schaaf-Yang syndrome (SYS). PWS is characterized by intellectual disability, obesity, poor muscle tone, distinct facial features, excessive daytime sleepiness and nighttime wakening. PWS is a...