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Skip to Search Results- 1Awadh, Abdullah
- 1Bourrie, Benjamin
- 1Greer, Michael S
- 1Kilic, Tolga
- 1Mohajerani, Seyed Amir
- 1O'Keefe-Markman, Caroline
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Type-1 Brassica napus Diacylglycerol Acyltransferases: Enzyme Characterization and Molecular Tools for Increasing Storage Lipid Production in Yeast
DownloadFall 2015
Diacylglycerol acyltransferase (DGAT) catalyzes the final step in the acyl-CoA- dependent biosynthesis of triacylglycerol (TAG). The level of DGAT activity may have a substantial effect on the flow of carbon into TAG in many organisms. In plants, yeast, and animals, two families of...
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Regulation of HCV Cell-to-Cell Spread by ADP-ribosylation factor 1-Dependent Regulation of Cytosolic Lipid Droplet Homeostasis
DownloadSpring 2018
Hepatitis C virus (HCV) infects cells via cell-free virions by direct cell-to-cell transmission. Entry of cell-free HCV virions has been fairly well-characterized. Several host factors involved in this process have been identified, including the cell surface receptors, tight junction molecules,...
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Fall 2013
The hepatitis C virus leads to chronic infection in the majority of infected individuals; however, in a minority of patients, acute infection is followed by viral clearance. The immune correlates of viral clearance are not yet clear, but have been extensively investigated, suggesting the role of...
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Immortalized human hepatocyte, an alternate model for the study of the propagation of HCV in vivo and in vitro
DownloadSpring 2011
The chimeric Alb-uPA SCID mouse that has been transplanted with human hepatocytes is a model to facilitate in vivo study of HCV. We explored further development of the model by using repopulation with immortalized human hepatocytes (IHH) in place of primary human hepatocyte (PHH) transplantation...
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Huh7.5 Cells Grown in Human Serum as a Model to Study the Effects of Hepatitis C Virus Infection on Lipid Catabolism
DownloadSpring 2018
Our goal is to study the additional elements of the mechanism of steatosis underlying hepatitis C virus (HCV) infection. Human hepatoma Huh7.5 cells cultured in human serum (HS) were used as a model to study the development of steatosis. Huh7.5 cells grown in HS media were chosen to study the...
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Exploring the Role of ADAM17 in Vascular Smooth Muscle Cells and Macrophages Within the Atherosclerotic Plaque
DownloadSpring 2024
Atherosclerosis, characterized by arterial fat deposits, is the root cause of many cardiovascular diseases. Plaque deposition results from a series of events initiated by elevated plasma cholesterol, inflammation of the arterial wall, cholesterol uptake, macrophage-derived foam cell formation,...
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Culture and Characterization of Kefir Organisms to Reproduce the Health Benefits of Traditional Kefir
DownloadSpring 2020
Fermented dairy products such as kefir have long been associated with a host of health benefits; however, the role that microbial composition has in these benefits has not been properly examined. This research aimed to examine how kefir impacts host metabolic health, as well as how alterations to...
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Challenges for Resource Allocation, Decision Making and Consideration of Social Values for Screening, Diagnosis and Treatment of Hepatitis C in Canadian Populations
DownloadFall 2018
Introduction: Health care system decision makers face challenges in allocating resources for screening, diagnosis and therapies for hepatitis C, caused by the highly infectious and blood borne hepatitis C virus (HCV) (WHO, 2014). Approximately 240,000 individuals are infected with HCV in Canada...