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Skip to Search Results- 2Levosimendan
- 1Calcium sensitizer
- 1Cardiomyopathy
- 1Dilated cardiomyopathy
- 1Heart failure
- 1Hypertrophic cardiomyopathy
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Fall 2011
The pumping of the heart is controlled at the molecular level by the calcium dependent interaction between troponin C (cTnC) and troponin I (cTnI). The central role this protein-protein interaction plays in the muscle contraction cascade makes it a prime target for the development of drugs for...
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Structure and Function of Cardiac Troponin C (TNNC1): Implications for Heart Failure, Cardiomyopathies, and Troponin Modulating Drugs
Download2015-01-01
Li, Monica X., Hwang, Peter M.
In striated muscle, the protein troponin complex turns contraction on and off in a calcium-dependent manner. The calcium-sensing component of the complex is troponin C, which is expressed from the TNNC1 gene in both cardiac muscle and slow-twitch skeletal muscle (identical transcript in both...