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Skip to Search Results- 1Aderibigbe, Ayodeji O.
- 1Al-Momany, Abass M T
- 1Chow, Aaron K.Y.
- 1Chu, Carmen Y.S.
- 1Elwi, Adam
- 1Haddad, George
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A novel mouse model of acute antibody-mediated transplant rejection shows simultaneous complement activating and anti-inflammatory effects of donor specific IgG antibodies
DownloadFall 2013
We developed a small animal model of pure antibody-mediated rejection (ABMR) by utilizing fully major histocompatibility complex (MHC) mismatched kidney allografts in mice. By examining resultant ABMR pathology, we show that terminal complement products C5a and C5b-9 are crucial in establishing...
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Spring 2015
Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...
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Fall 2014
An organoarsenic compound, 3-nitro-4-hydroxyphenyl arsenic acid (also known as Roxarsone), has been used as a feed additive. Roxarsone was approved by the Food and Drug Administration (FDA) to control diseases in poultry, and to improve weight gain, feed efficiency, and meat pigmentation....
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Spring 2015
The kidneys regulate total body fluid volume, acid-base status, and electrolyte composition through the filtration of large amounts of plasma by glomerular capillaries, followed by selective reabsorption of solutes and water by renal tubules. To sustain filtration, the hydraulic pressure within...
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Fall 2009
Human cells possess multiple nucleoside transporters (NTs) that belong to either the human equilibrative or concentrative NT (hENT: hENT1/2/3/4; hCNT: CNT1/2/3) families. In the kidney, coupling of apical hCNT3 activities to basolateral hENT1/2 activities is hypothesized to mediate renal...
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Fall 2012
The kidney anion exchanger 1 (kAE1) is crucial in the regulation of physiological pH by facilitating Cl-/HCO3- exchange. Inability to do so results in distal renal tubular acidosis (dRTA), which is more often due to mutations leading to mis-localization of kAE1, rather than complete abolishment...
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Fall 2016
The mammalian Na+/H+ exchanger isoform 1 (NHE1) is a ubiquitous plasma membrane protein that regulates intracellular pH by removing a proton in exchange for extracellular sodium. NHE1 is expressed in many tissues including the kidney where it has been demonstrated to play essential roles in pH...
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Fall 2013
Thrombotic microangiopathies are group of diseases that refer to clinical and pathological syndromes where endothelial injury results in the manifestations of capillary thrombosis, microangiopathic hemolytic anemia, schistocytosis, and can lead to renal failure. In this thesis we aimed to study...
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Fall 2018
Chloride intracellular channel (CLIC) proteins comprise six members CLIC1–CLIC6 in mammals and mediate functions not fully known. Their founding member was isolated from bovine kidney using the chloride channel inhibitor indanyloxyacetic acid-94, so CLICs were assumed to be typical anion...