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Skip to Search Results- 1Almohaya, Abdulellah
- 1Brophy, Taylor Raymond
- 1Dekker, Cornelia Ann Leanne.
- 1Fagan-Garcia, Katharine
- 1Griffiths, Cameron
- 1Jensen, Lionel D
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A large deletion virus reveals the presence of previously uncharacterized vaccinia virus inhibitors of NF-kB signaling
DownloadFall 2010
The classical Nuclear Factor kappa B (NF-κB) signaling pathway is an important regulator of inflammation and innate immune responses. Poxviruses, including vaccinia virus, encode multiple immune evasion proteins, including a growing number of NF-κB inhibitors. To determine if additional vaccinia...
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Antimicrobial Resistant Campylobacter species in the Food Chain: Understanding the Human Risk of Infection
DownloadFall 2022
Background: Campylobacter spp., commonly detected in poultry, are the third most common cause of foodborne illness in Canada. Campylobacter while self-limiting and typically only requiring supportive care treatment, can be resistant to antimicrobials important to human health. To better...
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Fall 2010
Mast cells are immune cells important in innate immunity. Besides their role in asthma and allergies, mast cells are critical effector cells against various pathogens. Mast cells are established to be protective against bacterial infections, but little is known about their functions in viral...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...
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Estimating the Seroprevalence of Cytomegalovirus (CMV), Epstein-Barr Virus (EBV) and the Risk of Transfusion-Transmitted and Community-Acquired CMV Infection in Solid Organ Transplant Donors and Recipients
DownloadFall 2019
Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are ubiquitous herpesviruses that establish lifelong, often asymptomatic, infections in healthy people, but are responsible for significant morbidity and mortality in certain hosts. CMV is the most common congenital infection worldwide, causing...
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Inhibition and enhancement of Respiratory Syncytial Virus replication by nucleoside analogues and bis(indole) compounds
DownloadSpring 2019
Respiratory syncytial virus (RSV) is an Orthopneumovirus that infects the epithelium of the airways. Severe RSV infection of the lower respiratory tract in infants is a leading cause of pediatric hospitalizations. RSV also causes substantial morbidity in immunocompromised and elderly populations....
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Spring 2020
Respiratory syncytial virus (RSV) is a ubiquitous respiratory pathogen that infects almost everyone by the age of two. In high-risk populations, such as infants and elderly individuals, RSV can infect the lower respiratory tract and cause severe symptoms, such as bronchiolitis or pneumonia. As a...
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Fall 2019
Parasite aggregation is a population-based metric in which many hosts harbour few parasites but some hosts are infected by a large number of parasites. The causes of aggregation are primarily attributed to heterogeneity in host exposure and susceptibility. However, parasites can exert numerous...
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Fall 2020
Infectious respiratory diseases, caused by viruses and bacteria that attack the respiratory system, constitute a serious threat in public health around the world. Pathogens can be transmitted in the air though large droplets or aerosols. As aerosols can linger in the environment for a prolonged...