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2012
Müller-Reichert, T., Greenan, G., O'Toole, E., Srayko, M., Lange, K.I.
As part of a multi-subunit ring complex, γ-tubulin has been shown to promote microtubule nucleation both in vitro and in vivo, and the structural properties of the complex suggest that it also seals the minus ends of the polymers with a conical cap. Cells depleted of γ-tubulin, however, still...
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Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning
Download2011
Dynein motors move along the microtubule (MT) lattice in a processive “walking” manner. In the one-cell Caenorhabditis elegans embryo, dynein is required for spindle-pulling forces during mitosis. Posteriorly directed spindle-pulling forces are higher than anteriorly directed forces, and this...
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An alternative physiological role for the EmhABC efflux pump in Pseudomonas fluorescens cLP6a
Download2011
Background Efflux pumps belonging to the resistance-nodulation-division (RND) superfamily in bacteria are involved in antibiotic resistance and solvent tolerance but have an unknown physiological role. EmhABC, a RND-type efflux pump in Pseudomonas fluorescens strain cLP6a, extrudes hydrophobic...
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The APETALA-2-Like Transcription Factor OsAP2-39 Controls Key Interactions between Abscisic Acid and Gibberellin in Rice
Download2010
Rothstein, Steven J., Bi, Yong-Mei, Zhu, Tong, El-kereamy, Ashraf, Beatty, Perrin H., Yaish, Mahmoud W., Good, Allen G.
The interaction between phytohormones is an important mechanism which controls growth and developmental processes in plants. Deciphering these interactions is a crucial step in helping to develop crops with enhanced yield and resistance to environmental stresses. Controlling the expression level...
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2010
Sensen, C.W., Goss, G.G., Childs, S.J., Zuccolo, J., Bau, J., Deans, J.P.
Background: The MS4A gene family in humans includes CD20 (MS4A1), FcRb (MS4A2), Htm4 (MS4A3), and at least 13 other syntenic genes encoding membrane proteins, most having characteristic tetraspanning topology. Expression of MS4A genes is variable in tissues throughout the body; however, several...
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2009
Wishart, D.S., Psychogios, N., Young, N., Xia, J.
Metabolomics is a newly emerging field of ‘omics’ research that is concerned with characterizing large numbers of metabolites using NMR, chromatography and mass spectrometry. It is frequently used in biomarker identification and the metabolic profiling of cells, tissues or organisms. The data...
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Hymenolepis diminuta (Cestoda) induces changes in expression of select genes of Tribolium confusum (Coleoptera)
Download2009
Belosevic, M., Shostak, A. W., Hitchen, S. J.
The flour beetle Tribolium confusum is a common experimental intermediate host for the tapeworm Hymenolepis diminuta, but while many aspects of their host-parasite interactions have been determined to have genetic basis, the genes involved have not been identified. In this paper, we report on the...
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2009
Lewis, A., Wishart, D.S., Guo, A.C., Gautam, B., Tzur, D., Sobsey, C.A., Shaykhutdinov, R., Fradette, R., De Souza, A., Cruz, J.A., Xiong, Y., Bouatra, S., Mandal, R., Psychogios, N., Sinelnikov, I., Vogel, H.J., Fang, L., Peng, J., Xia, J., Li, L., Knox, C., Shrivastava, S., Clements, M., Lim, E., Eisner, R., Cheng, D., Dawe, M., Zuniga, A., Young, N., Jia, L., Grenier, R., Hau, D.D., Huang, P., Nazyrova, A., Liu, P., Forsythe, I., Dong, E., Clive, D.
The Human Metabolome Database (HMDB, http:// www.hmdb.ca (http://www.hmdb.ca)) is a richly annotated resource that is designed to address the broad needs of biochemists, clinical chemists, physicians, medical geneticists, nutritionists and members of the metabolomics community. Since its first...
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The secretogranin II-derived peptide secretoneurin stimulates luteinizing hormone secretion from gonadotrophs.
Download2009
Chen, A., Grey, C.L., Wong, A.O.L., Somoza, G.M., López, G.C., Canosa, L.F., Zhao, E., Trudeau, V.L., Chang, J.P., Basak, A., Ko,W.
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a member of the glucagon/secretin peptide family, and its molecular structure is highly conserved in vertebrates. In this study, the functional role of PACAP in regulating GH release in the goldfish was investigated. Using...
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Large-scale proteome profile of the zebrafish (Danio rerio) gill for physiological and biomarker discovery studies
Download2009
De Souza, A. G., Goss, G. G., MacCormack, T. J., Wang, N., Li, L.
Abstract: Zebrafish are an important model in vertebrate genetics, developmental biology, physiology, and toxicology. In this study, we established the first large-scale proteome profile of a teleost fish tissue using a shotgun method based on two-dimensional liquid chromatography-electrospray...