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Fall 2018
Huntington’s disease (HD) is a monogenic neurodegenerative disorder characterized by progressive choreic movements, dystonia, motor incoordination, cognitive decline and behavioural changes. HD is caused by an abnormal increase in the number of CAG repeats in the exon 1 of the huntingtin (HTT)...
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Role of gangliosides in extracellular vesicle secretion in wild-type and Huntington's disease cell models
DownloadFall 2020
Gangliosides are sialic acid containing glycosphingolipids highly enriched in the brain that play vital roles in intercellular communication, cell signalling and calcium homeostasis. A decrease in the ganglioside levels in the brain has been associated with several neurodegenerative diseases....