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Skip to Search Results- 1Hashemi, Seyede Zohre
- 1Ju, Tingting
- 1Li, Jiaying
- 1Obiakor, Chinwe Vivien
- 1Rashed, Reem A
- 1Solis Ares, Maria
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Antimicrobial activity of flavan-3-ols and oligomeric proanthocyanidins from pea seed coats and grape seeds against food and gut bacteria
DownloadFall 2017
Proanthocyanidins and their monomeric subunits flavan-3-ols belong to the polyphenol group of flavonoids. They have been proposed to exert health promoting effects against cancer, Type 2 diabetes and coronary disease among other conditions. These health promoting effects are believed to be...
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Blood Glucose-attenuating Effects of Pea-derived Fractions: Exploration of Mechanisms of Action in a Rat Model of Glucose Intolerance
DownloadFall 2015
Pulses, including dried peas, are nutrient-dense foods rich in fibre that have shown efficacy in improving glucose control in diabetic subjects. The seed coats, in spite of being the highly fibrous part, are sometimes discarded as a food-processing by-product. We hypothesized that supplementing...
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Fall 2019
Changes in the gut microbiota have been correlated with positive and negative health outcomes; however, the mechanisms of causality in microbial modifications and resulting host responses are largely unknown. In this thesis, a mouse model was successfully established by colonizing mice with gut...
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Effect of Antimicrobial Exposure on Clostridioides difficile (C. difficile) Colonization of the Infant Gut Microbiota in the Canadian Healthy Infant Longitudinal Development (CHILD) Birth Cohort
DownloadSpring 2020
Introduction: Antimicrobial exposure in early life has been associated with gut microbiota dysbiosis and development of allergic diseases in childhood. In adults and older children, C. difficile is the major pathogen responsible for antibiotic-induced diarrhea but the effect of colonization with...
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Long-term effects of early-life gut microbiota perturbations on pancreatic islet development
DownloadFall 2021
Impaired secretion of insulin from pancreatic beta-cells, along with loss of cell mass, is one of the hallmarks of the pathogenesis of type 2 diabetes, a metabolic disorder characterized by chronic hyperglycemia. In humans, beta-cells’ ability to secrete insulin in response to glucose is acquired...
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Long-term Impacts of Early Life Antibiotic Exposure on Intestinal Microbiota and Metabolic Disease
DownloadFall 2015
Although genetic factors, diet choices and sedentary lifestyle have long been considered main risk contributors for obesity and diabetes mellitus, years of study show that these factors cannot fully explain the increasing rate of worldwide metabolic disease. Epidemiological studies in recent...
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THE EFFECT OF β-FRUCTANS ON INTESTINAL PERMEABILITY IN PATIENTS WITH ULCERATIVE COLITIS IN CLINICAL REMISSION
DownloadFall 2023
Introduction: β-fructans are non-digestible fermentable carbohydrates that are metabolized by commensal gut bacteria such as Faecalibacterium prausnitzii and Roseburia spp. By-products of β-fructans fermentation include short-chain fatty acids, shown to improve intestinal epithelial integrity and...