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Fall 2016

James, Kevin

Reovirus is a naturally benign virus that preferentially replicates in transformed cells and is currently undergoing clinical trials as a promising oncolytic therapy. In normal mouse fibroblasts, transformation by constitutively activated Ras oncogene is sufficient to promote reovirus infection....

2023-08-10

Al-musawi, Maryam

Spring 2019

O'Hara, Eóin

There is increasing concern surrounding the ability of livestock industries to meet the needs of the rising global population. The gastrointestinal microbiota of ruminants plays a critical role in feed degradation, host energy supply, but is also a substantial source of anthropogenic greenhouse...

2016

Dervishi, Elda, Ametaj, Burim N., Zhang, Guanshi, Dunn, Suzana M., Hailemariam, Dagnachew

Background Failure to expel fetal membranes within 24 h of calving is a pathological condition defined as retained placenta (RP). The objective of this investigation was to evaluate whether there are alterations in several selected serum variables related to innate immunity and carbohydrate and...

Fall 2023

Friedman, Timothy N.

The overarching idea of this thesis stemmed from previous work in our lab, where it was noticed that females and males exhibited different disease trajectories in a model of Multiple Sclerosis. Combined with our observation of different outcome metrics for peripheral nociception suggested that...

Spring 2015

Parsons, Brendon D

The innate immune system is an ancient line of resistance against intrusive microbial threats. This system integrates cellular, humoral, and barrier defenses to generate a protective immune response. These divisions are indispensable and conserved between Drosophila and mammals. Hemocytes are the...

2009

Baracos, Vickie E., Xue, Hongyu, Sawyer, Michael B., Field, Catherine J

Infectious complications are a major cause of morbidity and mortality from dose-intensive cancer chemotherapy. In spite of the importance of intestinal bacteria translocation in these infections, information about the effect of high-dose chemotherapy on gut mucosal immunity is minimal. We studied...

Fall 2024

Wass, Adam C

Multiple sclerosis (MS) is an autoimmune disease that is characterized by demyelination of central nervous system axons. Symptoms of MS are highly heterogenous, although some, such as motor deficits and chronic pain, are very common in those with the disease. Defined by the International...

Spring 2016

Liang, Guanxiang

Maintenance of the gut health of calves is vital because enteric infections are associated with high mortality during the pre-weaned period. The small intestine is the primary site of many enteric infections and plays an important role in protecting the host from pathogenic infection through both...