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Spring 2017
ADP-ribosylation factors (Arfs) play a central role in the regulation of vesicular trafficking through the Golgi. Arfs are activated on cis-Golgi membranes exclusively by the guanine nucleotide exchange factor (GEF) Golgi-specific BFA resistance factor 1 (GBF1), upon recruitment from cytosol....
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Evolution of the eukaryotic membrane trafficking system as revealed by comparative genomic and phylogenetic analysis of adaptin, golgin, and SNARE proteins
DownloadSpring 2020
All eukaryotic cells possess a complex system of endomembranes that functions in trafficking molecular cargo within the cell, which is not observed in prokaryotic cells. This membrane trafficking system is fundamental to the cellular physiology of extant eukaryotes, and includes organelles such...
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Functional characterization of class I Arfs and their Guanine Nucleotide Exchange Factors at the Golgi complex
DownloadFall 2009
We examined the function of ADP-ribosylation factors (Arfs) and their guanine nucleotide exchange factors (GEFs) that regulate recruitment of coat proteins on the Golgi complex. The large ArfGEF GBF1 localizes at the cis-Golgi complex while BIG1 and BIG2 localize at the trans-Golgi network...
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Fall 2020
The Golgi complex resides at the center of the cellular trafficking pathway, where it functions in the modification, sorting, and trafficking of over one third of human proteins to their correct cellular destination. Initiation of vesicle formation at the Golgi requires activation of small...