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Skip to Search Results- 2Macauley, Matthew S.
- 1Bubb, Abigail K.
- 1Chu, Thu
- 1Davies, Gideon J.
- 1Fajonyomi, Daniel Oluwamayowa
- 1Feldman, Mario F.
- 9Graduate and Postdoctoral Studies (GPS), Faculty of
- 9Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 3Chemistry, Department of
- 3Chemistry, Department of/Journal Articles (Chemistry)
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/R.E. Peter Biology Conference
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Spring 2023
Glycosylation is one of the most abundant and diverse post-translational modifications. Glycans participate in various key biological functions and processes including immunity, cell adhesion, endocytosis, exocytosis, molecular trafficking, and signal transduction. Previous work from our lab...
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Elevation of global O-GlcNAc levels in 3T3-L1 adipocytes by selective inhibition of O-GlcNAcase does not induce insulin resistance
Download2008
Bubb, Abigail K., Macauley, Matthew S., Davies, Gideon J., Vocadlo, David J. , Martinez-Fleites, Carlos
The O-GlcNAc post-translational modification is considered to act as a sensor of nutrient flux through the hexosamine biosynthetic pathway. A cornerstone of this hypothesis is that global elevation of protein O-GlcNAc levels, typically induced with the non-selective O-GlcNAcase inhibitor PUGNAc...
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Exploiting bacterial glycosylation machineries for the synthesis of a Lewis antigen-containing glycoprotein
Download2011
Hug, Isabelle, Reiz, Bela, Fentabil, Messele A., Klassen, John S., Whittal, Randy M., Zheng, Blake, Feldman, Mario F.
Glycoproteins constitute a class of compounds of increasing importance for pharmaceutical applications. The manipulation of bacterial protein glycosylation systems from Gram-negative bacteria for the synthesis of recombinant glycoproteins is a promising alternative to the current production...
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Exploiting novel Acinetobacter Oligosaccharyltransferases for the development of glycoconjugate vaccines against the Pneumococcus
DownloadSpring 2016
Vaccines bring many diseases under control, an example of which is the Streptococcus pneumoniae, or the Pneumococcus. Pneumococcus is one of the leading causes of meningitis in children under 5 years, and is responsible for almost a million child deaths annually, with more than 90 serotypes...
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Spring 2015
Acinetobacter baumannii remains a poorly understood, but very dangerous opportunistic pathogen. Though it lacks clear virulence traits expected of pathogens, it none the less poses a massive threat to the hospital system due to its inherent and acquired resistance to antibiotics, survival on...
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Fall 2015
Bacterial resistance to chemical and physical methods in food processing, and the consumers’ demand for food free of chemical additives challenge the food industry to identify new approaches for food preservation. Affordable and novel antimicrobial compounds from food derived sources are an...
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Spring 2021
While PrP is almost always found in the glycosylated state, there has been very little study attempting to explore the effects of the size of glycans, the composition of glycans, and the site of glycosylation on the stability of PrP. These effects can potentially play an important role in the...
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Fall 2011
Ovomucin is a bioactive egg white glycoprotein responsible for its gel-like properties and is believed to be involved in egg white thinning, a natural process that occurs during storage. Ovomucin is composed of two subunits: a carbohydrate-rich β-ovomucin and a carbohydrate-poor α-ovomucin....