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Skip to Search Results- 1Chaurasiya, Shyambabu
- 1DeSilva, Alan D
- 1Diaz Dussan, Diana M.
- 1Fung, Rachel D
- 1MacLeod, Sheena H
- 1Potts, Kyle G
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Binding, internalization, and transgene expression of an adenoviral vector retargeted to HER3/4
DownloadFall 2013
Adenoviruses (Ads) have been well studied for use in cancer gene therapy. However, low levels of the primary receptor, coxsackie-adenovirus receptor (CAR), in tumor cells has been shown to be a factor in low transgene expression. To increase Ad infection of breast cancer cells we constructed a...
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Combination Radiation Therapy and Oncolytic Vaccinia Virus Therapy in Preclinical Models of Glioma
DownloadSpring 2017
Gliomas are the most common primary malignant brain tumour in adults, with glioblastoma multiforme (GBM), the most common and most deadly form of glioma, making up over half of all diagnosed cancers in the brain/central nervous system. The standard of care for gliomas has remained unchanged for...
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Deletion of F4L (ribonucleotide reductase) in Vaccinia Virus Produces a Selective Oncolytic Virus and Promotes Anti-tumor Immunity with Superior Safety in Bladder Cancer
DownloadFall 2017
Overall recurrence of non-muscle-invasive bladder cancer (NMIBC) can be as high as 80% within 5 years of initial treatment. High-grade NMIBC has the greatest risk of recurrence and treatment for these patients includes surgery followed by intravesical therapy with the immunotherapeutic agent...
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Development of a Targeted Adenoviral Vector Expressing HSV-TK for use in Breast Cancer Gene Therapy and Analysis through Positron Emission Tomography
DownloadFall 2012
While adenoviral (Ad) vectors are the most commonly used gene delivery vector for human gene therapy, improvements must be made to increase Ad specificity to tumors if they are to be used for cancer gene therapy. Our goal is to target adenoviral vectors to breast cancer (BrCa) cells to induce...
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Effect of Adenovirus-mediated Decorin Gene Therapy on Fibrotic Remodeling in Tissue-engineered Skin
DownloadFall 2016
Background: Hypertrophic scar (HTS) is a fibroproliferative disorder of the skin that results in the development of painful, red, raised scar lesions. Transforming growth factor beta 1 (TGF-β1) has been implicated as a key driver of this disorder. Primarily, these effects include an increased...
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Versatile Polymer-Based Nanomedicines for Drug/Gene Delivery and Cell-based Therapy Applications
DownloadSpring 2021
Advances in polymer science and nanotechnology have allowed the development of biomaterials for cell-based applications, such as the delivery of a variety of drugs and genes, as well as supporting technologies, such as stem cell therapies, tissue engineering and cryopreservation. The progress in...
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Fall 2016
Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...