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Deciphering the molecular mechanisms underlying the pathobiology of esophageal squamous cell carcinoma
DownloadFall 2015
Esophageal squamous cell carcinoma (ESCC) is one of the most lethal cancers worldwide, largely due to a high frequency of tumor invasion/metastasis, chemoresistance and recurrence. In this study, we explored from different perspectives the molecular mechanisms behind these aggressive features of...
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Delineation of Molecular Mechanisms Underlying the Pathobiology of ALK-positive Anaplastic Large-cell Lymphoma
DownloadSpring 2017
ALK-positive anaplastic large-cell lymphoma (ALK+ALCL) is a rare type non-Hodgkin lymphoma of null/T cell original, preferentially occurs in children and young adults. Approximately 85% of ALK+ALCL patients carry the gene translocation t(2;5)(p23;q35), which results in the generation of the...
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The biological function and clinical significance of STAT1 in esophageal squamous cell carcinoma
DownloadFall 2016
Although esophageal cancer makes up only 1% of all the cancers in western countries, it is a common death cancer in other areas, especially China. Esophageal squamous cell carcinoma (ESCC) is the most common type of esophageal cancer in Chaoshan, an area with high incidence rate of this disease...