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Skip to Search Results- 1Akhnokh, Maria Kodsy
- 1BATCHU, SRI NAGARJUN
- 1Bai, Helin Daniel
- 1Bosnjak, Natasa
- 1Close, Anne-Françoise J
- 1Davis-Street, Janis.
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....
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Fall 2019
Postpartum weight retention (PPWR) is an important risk factor for long-term obesity. Accurate assessment and understanding of energy expenditure and other metabolic characteristics of postpartum women may improve weight management following childbirth. The overall aims of this research were to...
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Spring 2019
Energy expenditure forms the basis of all dietary recommendations. In patients with cancer, resting energy expenditure (REE) can be impacted by tumor burden, high systemic inflammation, and/or altered body composition. Total energy expenditure (TEE) and physical activity levels (PAL) have been...
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Spring 2016
Heart failure is associated with major changes in cardiac energy metabolism that decrease cardiac efficiency, which can reduce cardiac function. In severe heart failure there is a shift back toward a fetal heart metabolism, with a decrease in mitochondrial oxidative metabolism and increase in...
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Fall 2013
Deregulated TNF signaling with elevated or decreased levels of TNF-induced apoptosis causes numerous inflammatory and cancerous diseases. Thus, there is a clear need to identify cellular proteins that regulate cell fate in the presence of TNF. RNA interference technology provides an excellent...
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Insulin signaling, mitochondrial DNA copy number regulation and aging in Caenorhabditis elegans
DownloadFall 2010
Mitochondrial dysfunction is considered as a key mechanism of aging but little is known about the impact of mitochondrial biogenesis. Mitochondrial DNA (mtDNA) copy number control is an important aspect of mitochondrial biogenesis and is highly regulated in eukaryotic organisms. By studying mtDNA...
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Investigation of transcriptional and translational regulation of the Neurospora crassa alternative oxidase
DownloadFall 2018
Mitochondria are organelles found in most eukaryotes and supply the cell with the majority of its energy needs in the form of ATP. Most of the proteins needed for mitochondrial function are nuclear encoded. Therefore, mitochondria communicate their functional status to the nucleus, resulting in...