Search
Skip to Search Results- 1Abdrabou, Abdalla
- 1Aulakh, Amit
- 1Baedke, Jessica
- 1Bai, Xuechun
- 1Bosnjak, Natasa
- 1Burke, Lindsey Alison
-
Spring 2011
Forkhead (Fox) proteins are transcription factors that function in many processes including development, metabolism and cell cycle regulation. This gene family is divided into subfamilies that appear to originate from a common ancestor. I have identified the evolutionary selection pressures...
-
Genetic population structure of walleye (Sander vitreus) in northern Alberta and application to species management
DownloadFall 2010
Walleye (Sander vitreus) is an economically valuable freshwater fish throughout North America. In Alberta, pressure from sport fishing and commercial fishing make effective management and protection of this species crucial to its sustainability. Walleye from 12 Alberta lakes were genetically...
-
Spring 2024
Trembling aspen (Populus tremuloides Michx.) is a dioecious clonal tree species with broad distribution in North America. In dioecious species, sexes are predicted to perform differently, based on the principle of allocation and the energy costs associated with reproduction. Aspen reproduce...
-
Fall 2021
Clubroot disease, caused by Plasmodiophora brassicae, is a major threat to canola production. Cultivation of resistant cultivars is the key component in managing this disease. Canola is an important oilseed crop in the world; this includes the allopolyploid species Brassica napus L. (AACC genome,...
-
Fall 2019
The development of efficacious anticancer therapies has significantly improved the prognosis of childhood cancer patients at the price of predisposing survivors to extensive chronic health problems. Although not fatal, reducing treatment-related hearing loss (ototoxicity) among childhood cancer...
-
Spring 2018
Choroideremia is an X-linked monogenic inherited retinal disease. It affects males starting in their teenage years with night blindness followed by progressive vision loss starting in the peripherals and ending with total vision loss late in life. It is estimated that 1 in 50,000 individuals...
-
Fall 2017
NPAS3 encodes a transcription factor of the bHLH-PAS family, which has been robustly associated with neurodevelopmental and psychiatric disorders with intellectual disability as a common feature. NPAS3 was initially discovered as a schizophrenia-associated gene in a family with a translocation...
-
Innate Immunity and the Retinal Pigment Epithelium in Gene Therapy for Inherited Retinal Disorders
DownloadFall 2021
Background: The photoreceptors are post-mitotic (no longer dividing), so the eye has evolved several unique immunological mechanisms to protect the photoreceptors and prevent vision loss. Inherited retinal disorders occur when mutations disrupt normal retinal function and photoreceptors die....
-
Fall 2020
Rac1 is a small GTPase that belongs to the Rho family. Like other Rho family GTPases, it mediates a plethora of cellular effects, including regulation of cytoarchitecture, cell size, cell adhesion, cell polarity, cell motility, proliferation, apoptosis/survival, and membrane trafficking. The...
-
Fall 2019
Cilia are microtubule-based structures that project from nearly every cell in the vertebrate body. While cilia in different contexts can have either sensory or motile functions, all cilia rely upon a core set of genes. When these genes are mutated either singly or in various combinations, a...