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Skip to Search Results- 1Abdul Rahman, Siti Aishah
- 1Alles, Sascha R
- 1Asha, Anika Benozir
- 1Chen, Yishen
- 1Chung, Jun-Mo.
- 1Dimopoulos, Ioannis
- 5Centre for Neuroscience
- 3Department of Pharmacology
- 3Department of Physiology
- 3Neuroscience
- 2Medical Sciences-Medical Genetics
- 2Physical Education and Recreation
- 2Stickland, Michael (Medicine and Dentistry)
- 2Tse, Amy (Centre for Neuroscience and Department of Pharmacology)
- 1Ballanyi, Klaus (Physiology Department, University of Alberta)
- 1Chen, Xing-Zhen (Physiology)
- 1Clayton T. Dickson (Psychology, Physiology, Anesthesia and Pain Medicine, Neuroscience and Mental Health Institute)
- 1Colmers, William F. (Pharmacology)
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Fall 2023
Sleep is a vital neurobiological process, yet despite its fundamental significance, delineating the endogenous neural pathways involved has been slow to progress due to a lack of diverse sleep models. Anesthesia, which has direct behavioural parallels to natural sleep, and which is often linked...
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Fall 2022
The reason and functional relevance of why we sleep continues to perplex researchers. One fundamental reason behind why sleep remains a mystery is because it is challenging to study given how easily it is disrupted. Anesthesia has been suggested to be a model for studying sleep given the...
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Fall 2022
Biofouling is a serious problem in the medical, marine, and several other industrial fields as it poses significant health risks and financial losses. Therefore, there is a great need to endow surfaces with antifouling and antimicrobial properties to mitigate biofouling. For long-term biofouling...
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Pharmacological and Fluorometric Assessment of Neuronal KCNQ Channels, and Implications for Understanding Neurological Disease
DownloadSpring 2020
Epilepsy affects 60 million people worldwide, and encompasses the most common forms of neurological disorders. Epilepsy manifests in diverse ways in patients, ranging from mild cognitive effects, to seizures, to the more severe epileptic encephalopathy. While many pharmacological approaches exist...
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Using EEG to examine inhibitory abilities in children: The effects of time pressure, physical activity, and emotion
DownloadFall 2018
The ability to inhibit inappropriate actions and irrelevant information is crucial for adaptive functioning. Inhibitory skills emerge early in life, with significant growth occurring during the period of early and middle childhood. The objective of this dissertation was to utilize...
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The pulmonary vasculature during exercise in health and mild chronic obstructive pulmonary disease
DownloadFall 2017
The purpose of this dissertation was to characterize the response of the pulmonary vasculature to exercise in health (including a pharmacological intervention) and in individuals with mild chronic obstructive lung disease. The first project studied the effect of a dopamine receptor blockade on...
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The Effect of Dopamine on Pulmonary Diffusing Capacity and Capillary Blood Volume Responses to Exercise
DownloadFall 2017
Pulmonary diffusing capacity increases during exercise to meet the increasing oxygen (O2) demand of the body. Expansion of pulmonary capillary blood volume (Vc) and diffusing membrane capacity (Dm) are important contributors to the increased diffusing capacity observed during upright cycle...
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Characterizing the Mesolimbic Dopamine Reward Pathway in a Magel2-null Mouse, a Model of Prader-Willi Syndrome
DownloadFall 2016
Prader-Willi Syndrome (PWS) is a genetic disorder characterized by extreme hyperphagia that can lead to severe obesity. The abnormal motivation to eat in PWS suggests a disruption in the hedonic feeding pathway, which is feeding based on reward as opposed to physiological need. Hedonic feeding is...
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Spring 2016
This thesis examines the cellular basis of the acute (<1 hour) anti-allodynic actions of the clinically-approved neuropathic pain drug gabapentin (GBP) in rats at the level of the spinal dorsal horn and primary somatosensory cortex. Although the clinical effectiveness of the alpha-2-delta (α2δ)...
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Fall 2015
Polycystic kidney disease (PKD) protein 2 Like 1 (PKD2L1), also called transient receptor potential polycystin-3 (TRPP3), regulates Ca2+-dependent hedgehog signalling in primary cilia, intestinal development and sour tasting but with an unclear mechanism. PKD2L1 is a Ca2+-permeable cation channel...