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Skip to Search Results- 2Al Sayah, Fatima
- 2Elamy, Abdel-Halim H
- 1Achtymichuk, Karly A
- 1Adame Perez, Stephany
- 1Akin, Oguz
- 1Akinwumi, Segun M
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Spring 2015
Protein silencing by small interfering RNA (siRNA) is a promising treatment strategy for cancer as over-expression of proteins is largely responsible for cancer cells’ infinite proliferation, evasion of cell death and multi-drug resistance. However, siRNAs require a carrier as their biological...
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Long-term Impacts of Early Life Antibiotic Exposure on Intestinal Microbiota and Metabolic Disease
DownloadFall 2015
Although genetic factors, diet choices and sedentary lifestyle have long been considered main risk contributors for obesity and diabetes mellitus, years of study show that these factors cannot fully explain the increasing rate of worldwide metabolic disease. Epidemiological studies in recent...
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Fall 2019
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide. Abnormal levels of circulating lipids (dyslipidemia) is a well-known risk factor for CVD. Traditionally, fasting lipids, inclusive of low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC), have...
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Fall 2009
Islet transplantation has the potential to be an effective treatment for patients with type 1 diabetes. However, a shortage of human donor islets and the need for continuous immunosuppressive therapy currently limit this therapy to patients with brittle type 1 diabetes. Neonatal pigs may...
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Mechanisms of Pharmacists Interventions on Medication Management and Adherence in Patients with Type 2 Diabetes
DownloadSpring 2014
Optimal management of type 2 diabetes requires a collaborative, team-based approach; however, the role of pharmacists on these teams has not been well-defined. In the first study of this thesis, a systematic review examined components of pharmacist interventions to improve adherence to oral...
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Spring 2014
Each patient with Type-1 diabetes must decide how much insulin to inject before each meal to maintain an acceptable level of blood glucose. The actual injection dose is based on a formula that takes current blood glucose level and the meal size into consideration. While following this insulin...
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Fall 2017
Epstein-Barr virus (EBV) is a “kissing disease virus” that has infected more than 95% of the adult human population. It has been associated with diseases such as Acute Infectious Mononucleosis (AIM) and post-transplant lymphoproliferative disorder (PTLD). The kinetics of primary EBV infection has...
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Non-fasting remnant cholesterol as a predictor for cardiovascular disease risk in Canadians with and without diabetes mellitus in the Alberta’s Tomorrow Project
DownloadFall 2022
Cardiovascular disease (CVD) is a leading cause of death in Canada, and its risk of development is 3 times greater in those with diabetes mellitus (DM). Fasting low-density lipoprotein cholesterol (LDL-C) is the traditional lipid biomarker used in CVD risk assessment. While lowering LDL-C does...
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Spring 2012
Immigrant-receiving countries like Canada must meet the challenge of tuberculosis (TB) in their foreign-born populations. One puzzling question is why, despite fluctuating levels of immigration from high incidence source countries, only modest variations in foreign-born TB incidence have been...
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Nutritional Factors Impacting Intestinal Lipid Metabolism Using a Model of Low Birth Weight Swine
DownloadSpring 2018
Introduction: Non-communicable diseases (NCDs) such as obesity, type 2 diabetes (T2D) and cardiovascular disease (CVD) are increasing at an alarming rate globally. A common feature in these conditions is increased adiposity leading to insulin resistance (IR). Dyslipidemia is a major contributing...