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Author / Creator / Contributor
- 1Barakat, Khaled H.
- 1Dronyk, Ashley D
- 1Freschauf, Gary
- 1Gentile, Francesco
- 1Jiang, Bingcheng
- 1Khairy, Mostafa
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Role of human polynucleotide kinase/phosphatase (PNKP) in nuclear and mitochondrial DNA repair
DownloadFall 2015
DNA is continuously under stress from the insults inflicted by both endogenous and exogenous agents. These agents include endogenous reactive oxygen species (ROS), ionizing radiation (IR) and many common chemotherapeutic drugs, which can inflict a plethora of DNA lesions including abasic sites,...
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Spring 2024
DNA double-strand breaks (DSBs) are considered the most deleterious DNA lesions. Unrepaired or incorrectly repaired DSBs can lead to cell cycle arrest, apoptosis, or over time, the accumulation of mutations and chromosomal abnormalities that give rise to cancer. The repair of DSBs by homologous...
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