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Spring 2016
Remarkable progress has been made in terms of developing gold nanoparticle (AuNP) based colorimetric systems for biodiagnostics. There are two general strategies: the target analyte triggers assembly leading to a color change from red solution to blue precipitated AuNPs; the target analyte...
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Synthesis, Characterization and Biological Studies of the Phospholipid Coated Gold Nanoparticles (GNPs)
DownloadFall 2013
Gold nanoparticles (GNPs) have been applied as diagnostic and therapeutic agents because they can be targeted, localized, and be heated to cause cell death. However, their use has been limited by their relatively low biocompatibility. In this work, we coated the GNPs surface by a biocompatible...
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Fall 2014
The assembly of nanoparticle building blocks into more complex nanostructures has important applications in analytical chemistry, materials science, medical science, optics, and electronics. Due to its exquisite specificity and programmable nature, DNA has emerged as a very promising biomolecule...
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The Influence of Specific Ions and System Architecture on the Recognition and Reactivity of Two Charged Materials: DNA-Modified Gold Nanoparticle Aggregates and Planar Silica
DownloadFall 2014
DNA functionalized gold nanoparticles (GNP–DNA) offer simple colorimetric nucleic acid sensing with high selectivity and sensitivity. Consequently, they are promising in genetic profiling, disease diagnostics, and forensic applications. In the presence of a target nucleic acid, GNP–DNA forms...
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Fall 2014
Developing a simple, general, and isothermal self-replicating system is one of the key requirements for a simplified detection platform for nucleic acid sequences specific to a disease causing microrganism. One of the challenges in achieving nucleic-acid templated isothermal amplification is that...
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Tuning the Surface Composition, Spatial Arrangement, and Thermal Release Behavior of DNA-Gold Nanomaterials
DownloadFall 2013
Combining multiple functions and controlling their relative organization on the surface, as well as controlling the release of payloads will be essential properties of nanomaterials for future medical applications. In this thesis we studied these properties using as a model DNA-gold...