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Skip to Search Results- 8Chan, Catherine B.
- 5Wheeler, Michael B.
- 4Koshkin, Vasilij
- 4Willows, Noreen D.
- 3Field, Catherine J.
- 3Gänzle, Michael G.
- 37Graduate and Postdoctoral Studies (GPS), Faculty of
- 37Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 22Agricultural, Food and Nutritional Science, Department of
- 22Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 5WISEST Summer Research Program
- 5WISEST Summer Research Program/WISEST Research Posters
- 37Thesis
- 29Article (Published)
- 4Conference/Workshop Poster
- 3Image
- 3Research Material
- 2Conference/Workshop Presentation
- 18Department of Agricultural, Food, and Nutritional Science
- 3Department of Biological Sciences
- 3Department of Medicine
- 2Department of Physiology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Agricultural, Food and Nutritional Science
- 2Field, Catherine (Agricultural, Food and Nutritional Science)
- 1Alexander, R Todd (Paediatrics)
- 1Baker, Glen (Psychiatry)
- 1Baracos, Vickie (Oncology and Agricultural, Food and Nutritional Science)
- 1Bell, Rhonda (Agricultural, Food & Nutritional Science)
- 1Bell, Rhonda (Agricultural, Food and Nutritional Science)
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2004
Zhang, Chen-Yu, Chan, Catherine B., Koshkin, Vasilij, Wheeler, Michael B., Lowell, Bradford B., Joseph, Jamie W., Saleh, Monique C., Sivitz, William I.
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–)...
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Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic α-cells
Download2005
Chan, Catherine B., Wheeler, Michael B., Asghar, Zeenat, Diao, Jingyu
The insulin receptor (IR) and its signaling appear to be essential for insulin secretion from pancreatic β-cells. However, much less is known about the role of the IR in α-cells. To assess the role of the IR in glucagon and insulin secretion, we engineered adeno-viruses for high efficiency small...
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2018-10-16
SSHRC NFRF-E awarded 2019: With the requested funding, I will apply my expertise in T cells and metabolism to identify new potential metabolic drugs that can enhance immune function. We hypothesize that a Insulin-Resistance (IR)-related immune and metabolic defect contributes to increased risk of...
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Impact of a low fructose, low glycemic index and low glycemic load dietary intervention on liver function, body composition and cardio metabolic risk factors in children and adolescents with nonalcoholic fatty liver disease
DownloadSpring 2013
Nonalcoholic fatty liver disease (NAFLD) is a common liver disease in obese children. Diets high in added fructose (high fructose corn syrup; HFCS)/glycemic index (GI)/glycemic load (GL) in children with NAFLD are associated with increased inflammation and liver dysfunction. We hypothesized that...
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Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity
Download2010
Kuo, Ming-Shang, Dyck, Jason R. B., Sletten, Torunn, Proctor, Spencer D., Jacobs, René L., Lingrell, Susanne, Cao, Guoqing, Peake, David A., Kennedy, Brian P., Zhao, Yang, Vance, Dennis E., Koonen, Debby P. Y., Su, Brian
Phosphatidylcholine (PC) is synthesized from choline via the CDP-choline pathway. Liver cells can also synthesize PC via the sequential methylation of phosphatidylethanolamine, catalyzed by phosphatidylethanolamine N-methyltransferase (PEMT). The current study investigates whether or not hepatic...
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Increased rate of fatty acid uptake and plasmalemmal fatty acid transporters in obese Zucker rats
Download2001
Arumugam, Yoga, Luiken, Joost J. F. P., Dyck, David J., Bonen, Arend, Tandon, Narendra N., Pelsers, Maurice M. L., Bell, Rhonda C., Turcotte, Lorraine P., Glatz, Jan F. C.
Giant vesicles were used to study the rates of uptake of long-chain fatty acids by heart, skeletal muscle, and adipose tissue of obese and lean Zucker rats. With obesity there was an increase in vesicular fatty acid uptake of 1.8-fold in heart, muscle and adipose tissue. In some tissues only...
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Let’s not Sugar-Coat it: Exploring Differences of Sugar Consumption Behaviours During Pregnancy Through Focused Ethnography
DownloadFall 2012
Excessive sugar consumption may adversely affect maternal and fetal health. This study explored influences on women’s sugar consumption behaviours during pregnancy using focused ethnography. Fifteen pregnant women were interviewed and qualitative content analysis was used to inductively derive...
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Limited mitochondrial permeabilization is an early manifestation of palmitate-induced lipotoxicity in pancreatic ß-cells
Download2008
Wheeler, Michael B., Chan, Catherine B., Dai, Feihan F., Koshkin, Vasilij, Robson-Doucette, Christine A.
Involvement of the mitochondrial permeability transition (MPT) pore in early stages of lipotoxic stress in the pancreatic β-cell lines MIN6 and INS-1 was the focus of this study. Both long term (indirect) and acute (direct) effects of fatty acid (FA) application on β-cell susceptibility to...