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Skip to Search Results- 5Chan, Catherine B.
- 5Wheeler, Michael B.
- 4Gänzle, Michael G.
- 4Koshkin, Vasilij
- 4Proctor, Spencer D.
- 3Chakrabarti, Subhadeep
- 48Graduate and Postdoctoral Studies (GPS), Faculty of
- 48Graduate and Postdoctoral Studies (GPS), Faculty of /Theses and Dissertations
- 27Agricultural, Food and Nutritional Science, Department of
- 27Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Pharmacy and Pharmaceutical Sciences, Faculty of
- 2Biological Sciences, Department of
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Contributions of Bim and Nur77 to multiple mechanisms of T cell tolerance following high affinity antigen encounter
DownloadSpring 2015
Prevention of autoimmune disease requires the elimination or inactivation of T cells that are highly reactive to self-peptides. During T cell development in the thymus, self-reactive thymocytes undergo negative selection upon receiving a high affinity T cell receptor (TCR) signal following...
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Drug-disease interaction: effect of inflammation on the pharmacological response to calcium channel blockers
DownloadFall 2010
The present research is focused on the topic of inflammation-drug interaction. Inflammation complicates many human diseases and conditions ranging from obesity to cancer. Therefore, the study of the effect of inflammation on drug pharmacokinetics and pharmacodynamics is pivotal. First, we tested...
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Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative study
Download2015
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
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Effects of Egg White Derived Peptides on Metabolic Syndrome Complications: Hypertension, Inflammation, and Insulin resistance
DownloadSpring 2018
Metabolic syndrome (MetS), a cluster of several abnormalities of hypertension, inflammation, glucose intolerance and dyslipidemia, enhances a personâs risk for cardiovascular disease and type 2 diabetes. The number of people with MetS is increasing largely worldwide. The multi-faceted nature of...
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Effects of Inflammation and Non-Steroidal Anti-Inflammatory Drugs on Renin-Angiotensin System and Cytochrome P450 Metabolites of Arachidonic Acid
DownloadSpring 2016
Patients suffering from inflammatory disorders are at higher risk of cardiovascular (CV) morbidity and mortality compared to general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation associated with inflammatory disorders such as rheumatoid...
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Spring 2014
Inflammation is involved in the pathogenesis of some cardiovascular diseases and contributes to the observed increased overall mortality rate. It also influences the action and disposition of drugs including some of the cardiovascular agents that are commonly used by patients with inflammatory...
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Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats
Download2013
Majumder, Kaustav, Kaufman, Susan, Chakrabarti, Subhadeep, Morton, Jude S., Panahi, Sareh, Wu, Jianping, Davidge, Sandra T.
Background There is a growing interest in using functional food components as therapy for cardiovascular diseases such as hypertension. We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and...
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Fall 2016
Multiple sources suggest that insulin resistance and derangements of cardiac metabolism are among the earliest signs of type-2 diabetes detected in the heart. Unfortunately, limited evidence reflects early changes in cardiac mitochondrial metabolism linked to the development of this disease....