Search
Skip to Search Results- 15Young, T. Kue
- 7Proctor, Spencer D.
- 5Chan, Catherine B.
- 5Wheeler, Michael B.
- 5Willows, Noreen D.
- 4Field, Catherine J.
- 88Graduate and Postdoctoral Studies (GPS), Faculty of
- 88Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 42Agricultural, Food and Nutritional Science, Department of
- 42Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 17School of Public Health
- 17School of Public Health/Journal Articles (Public Health)
- 88Thesis
- 70Article (Published)
- 2Conference/Workshop Presentation
- 2Image
- 2Research Material
- 1Article (Draft / Submitted)
- 15Department of Agricultural, Food, and Nutritional Science
- 10Faculty of Pharmacy and Pharmaceutical Sciences
- 7Department of Medicine
- 6Medical Sciences-Paediatrics
- 4Centre for Neuroscience
- 4Department of Biological Sciences
- 2Baker, Glen (Psychiatry)
- 2Brocks, Dion (Pharmacy and Pharmaceutical Sciences)
- 2Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 2Jamali, Fakhreddin (Faculty of Pharmacy and Pharmaceutical Sciences)
- 2Kerr, Bradley (Anesthesiology and Pain Medicine)
- 2Proctor, Spencer (AFNS)
-
The analysis of cytokine regulation of macrophage antimicrobial responses of the goldfish (Carassius auratus L.)
DownloadFall 2011
Inflammation is a highly regulated immune response to tissue damage, infiltrating pathogens or both. Cells of the myeloid lineage such as macrophages are indispensable for the initiation, progression and resolution of inflammation. Macrophages possess an armamentarium of antimicrobial responses...
-
2012
Birch, Daniel W., Gill, Richdeep S., Karmali, Shahzeer, Whitlock, Kevin
Obesity has become a major issue for healthcare providers as its prevalence continues to increase throughout the world. The literature suggests that increased body mass index (BMI) is associated with the development of certain cancers such as colorectal cancer (CRC). Consequently, CRC surgeons...
-
The characterization of mitochondrial permeability transition (MPT) in clonal pancreatic beta cells: Multiple modes and regulation
Download2004
Chan, Catherine B., Bikopoulos, George, Koshkin, Vasilij, Wheeler, Michael B.
Mitochondrial permeability transition (MPT), which contributes substantially to the regulation of normal mitochondrial metabolism, also plays a crucial role in the initiation of cell death. It is known that MPT is regulated in a tissue-specific manner. The importance of MPT in the pancreatic...
-
The effect of oral lipids and lipoproteins on the biodistribution, metabolism and electrocardiographic side-effects of halofantrine
DownloadSpring 2011
In the past, hyperlipidemia (HL) has been shown to affect the pharmacokinetic and pharmacodynamic properties of lipophilic drugs extensively bound to lipoproteins, including halofantrine (HF). The present thesis examined the effect of HL on the biodistribution, metabolism and electrocardiographic...
-
The effects of antidepressants on the phenotype of activated microglia and ischemia-injured cortical neurons
DownloadFall 2013
Depression is one of the most common disorders appearing following a stroke and is also a major factor limiting recovery and rehabilitation in stroke patients. Several antidepressants have shown to have anti-inflammatory properties within the central nervous system (CNS). The major source of...
-
The Effects of Elements of Cardiometabolic Syndrome on Metformin Disposition: Obesity and Hyperlipidemia
DownloadFall 2015
The influences of obesity, Roux-en-Y gastric bypass bariatric (RYGB) surgery and hyperlipidemia on metformin pharmacokinetics (PK) were investigated. A sensitive and novel HPLC-UV reverse phase assay method was developed and utilized. Detection and mass characterization for metformin metabolites...
-
Fall 2019
Background: Functional mobility is an important factor associated with quality of life. However, it is often compromised in individuals with obesity due to changes in body function and structures. With excessive adipose tissue accumulation, some individuals have a shifted center of mass,...
-
Spring 2016
The prevalence of obesity worldwide has increased in the last few decades. The risk of obesity comes from its association with various clinical diseases especially cardiovascular diseases and diabetes. In this thesis, we assessed the expression of some drug metabolizing enzymes and transport...
-
The interaction of phenelzine with human monoamine oxidase B: characterization and consequences
DownloadSpring 2022
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor developed in the 1960s which has been used clinically for psychiatric conditions such as depression and anxiety disorders. However, despite over 60 years of research, the mechanism by which PLZ exerts its effects on MAO has yet to be...