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- 6Clostridium difficile
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- 7Gänzle, Michael G.
- 3Valcheva, Rosica
- 2Armstrong, Glen D.
- 2Dieleman, Levinus
- 2Dieleman, Levinus A.
- 2Dingle, Tanis C.
- 7Agricultural, Food and Nutritional Science, Department of
- 7Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 5Graduate and Postdoctoral Studies (GPS), Faculty of
- 5Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 2Chemistry, Department of
- 2Chemistry, Department of/Journal Articles (Chemistry)
- 1Brindley, David N. (University of Alberta, Biochemistry)
- 1Ganzle, Michael (Agricultural, Food, and Nutritional Science)
- 1Klassen, John S (Chemistry)
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- 1McMullen, Lynn (Agricultural, Food, and Nutritional Science)
- 1McMullen, Lynn M. (Agricultural, Food, Nutritional Science)
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Spring 2016
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....
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Use of the fluorescent probe LAURDAN to label and measure inner membrane fluidity of endospores of Clostridium spp.
Download2012-10-01
Hofstetter, Simmon, Denter, Christian, Winter, Roland, McMullen, Lynn M., Gänzle, Michael G.
A method for measuring the fluidity of inner membranes of populations of endospores of Clostridium spp. with a fluorescent dye was developed. Cells of Clostridium beijerinckii ATCC 8260 and Clostridium sporogenes ATCC 7955 were allowed to sporulate in the presence of...