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Skip to Search Results- 2Clavam
- 1Clavulanic acid
- 1Gene clusters
- 1Paralogous genes
- 1Phosphorylation
- 1Streptomyces antibioticus Tü1718
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Spring 2011
Production of clavams (including clavulanic acid, a potent β-lactamase inhibitor) has been studied in Streptomyces clavuligerus. All clavams share the early biosynthetic steps. However, many of the late steps of the pathway remain unclear. Streptomyces antibioticus Tü1718 was chosen for this...
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Spring 2011
Streptomyces clavuligerus is capable of producing various secondary metabolites including clavulanic acid. The biosynthetic pathway of clavulanic acid is partially shared with other structurally related 5S clavams. The first reaction involved in clavam biosynthesis is catalyzed by...