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Skip to Search Results- 4Chakrabarti, Subhadeep
- 4Field, Catherine J.
- 4Klassen, John S.
- 4Liu, Lan
- 4Lowary, Todd L.
- 4Proctor, Spencer D.
- 66Graduate and Postdoctoral Studies (GPS), Faculty of
- 66Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 23Agricultural, Food and Nutritional Science, Department of
- 23Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 4Chemistry, Department of
- 4Chemistry, Department of/Journal Articles (Chemistry)
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Development of Polymeric Micelles for Site Specific Delivery of Nonsteroidal Anti-Inflammatory Drugs: Effect on the Cardiovascular Risk in an Experimental Model of Arthritis
DownloadFall 2019
Non-steroidal anti-inflammatory drugs (NSAIDs), which inhibit cyclooxygenase (COX) enzymes, are among the most widely used medications worldwide with proven efficacy in controlling inflammation and pain associated various disease conditions. The chronic systemic use of most NSAIDs, however, is...
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Dietary oxysterols are incorporated in plasma triglyceride rich lipoproteins, increase their susceptibility to oxidation and increase aortic cholesterol concentration of rabbits
Download1998
Mamo, John C. L., Croft, Kevin D., Vine, Donna F., Mori, Tetsuya, Beilin, Lawrence J.
Early fatty streaks and advanced lesions are characterized by the deposition of cholesterol and cholesterol oxidation products (oxysterols). Oxysterols have been shown to be cytotoxic and pro-atherogenic compared to cholesterol and are found in cholesterol-rich processed foods. The consumption of...
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Spring 2015
Cholesterol is well known for its adverse cardiovascular effects, however it has crucial cellular roles. For instance, cholesterol is a key component of eukaryotic cell membranes and constitutes the principle steroid hormone precursor in most animals. Cellular cholesterol concentrations have to...
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Drug-disease interaction: effect of inflammation on the pharmacological response to calcium channel blockers
DownloadFall 2010
The present research is focused on the topic of inflammation-drug interaction. Inflammation complicates many human diseases and conditions ranging from obesity to cancer. Therefore, the study of the effect of inflammation on drug pharmacokinetics and pharmacodynamics is pivotal. First, we tested...
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Effect of Cholesterol Accumulation on the Metabolism of Amyloid Precursor Protein (APP) in Cultured N2a Cells
DownloadFall 2015
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder believed to be triggered by the accumulation of β-amyloid (Aβ) peptides derived from the proteolytic processing of amyloid precursor protein (APP). Accumulated evidence has shown that alterations in the levels and/or subcellular...
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Effects of aerobic training on the host systemic milieu in patients with solid tumors: An exploratory correlative study
Download2015
Stevens, Robert D., Courneya, Kerry S., Inman, Brant A., Muehlbauer, Michael, Nelson, Erik R., Jasper, Jeff, Field, Catherine J., Jones, Lee W., Glass, Oliver K., Bain, James R., Broadwater, Gloria, Goruk, Susan, Hirschey, Matthew D., Mackey, John R.
background: Few studies have investigated the effects of exercise on modulation of host factors in cancer patients. We investigated the efficacy of chronic aerobic training on multiple host-related effector pathways in patients with solid tumours. patients and methods: Paired peripheral blood...
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Effects of Egg White Derived Peptides on Metabolic Syndrome Complications: Hypertension, Inflammation, and Insulin resistance
DownloadSpring 2018
Metabolic syndrome (MetS), a cluster of several abnormalities of hypertension, inflammation, glucose intolerance and dyslipidemia, enhances a personâs risk for cardiovascular disease and type 2 diabetes. The number of people with MetS is increasing largely worldwide. The multi-faceted nature of...
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Effects of Inflammation and Non-Steroidal Anti-Inflammatory Drugs on Renin-Angiotensin System and Cytochrome P450 Metabolites of Arachidonic Acid
DownloadSpring 2016
Patients suffering from inflammatory disorders are at higher risk of cardiovascular (CV) morbidity and mortality compared to general population. Nonsteroidal anti-inflammatory drugs (NSAIDs) are used to treat pain and inflammation associated with inflammatory disorders such as rheumatoid...
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Spring 2014
Inflammation is involved in the pathogenesis of some cardiovascular diseases and contributes to the observed increased overall mortality rate. It also influences the action and disposition of drugs including some of the cardiovascular agents that are commonly used by patients with inflammatory...
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Egg-derived tri-peptide IRW exerts antihypertensive effects in spontaneously hypertensive rats
Download2013
Majumder, Kaustav, Kaufman, Susan, Chakrabarti, Subhadeep, Morton, Jude S., Panahi, Sareh, Wu, Jianping, Davidge, Sandra T.
Background There is a growing interest in using functional food components as therapy for cardiovascular diseases such as hypertension. We have previously characterized a tri-peptide IRW (Ile-Arg-Trp) from egg white protein ovotransferrin; this peptide showed anti-inflammatory, anti-oxidant and...