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1996

Gamble, James.

Spring 2015

MacDonald, Christine, L

Background: Heart transplant is life-saving for children with end-stage congenital heart disease or acquired heart failure. Critical illness following transplantation can include acute kidney injury (AKI). There is little data on the epidemiology of, risk factors for, or impact on outcomes of...

Fall 2015

Abdelmoneim, AS

All drugs have the potential to cause adverse events that can result in hospitalization or death. In order to protect the public health, it is critical to employ methods to detect and assess adverse drug events in a timely manner. One of the most controversial and long standing drug safety issue...

2001-01-01

Guo, Lei, Lynch, Jeffrey, Nakamur, Kimitoshi, Fliegel, Larry, Kasahara, Hideko, Izumo, Seigo, Komuro, Issei, Agellon, Luis B., Michalak, Marek

Calreticulin, a Ca2+ binding chaperone of the endoplasmic reticulum, is also highly expressed in the embryonic heart, and knockout of the calreticulin gene is lethal during embryogenesis because of impaired cardiac development. The protein is down-regulated after birth, and elevated expression of...

Fall 2022

Vyhlidal, Margaret J.

Menisci are fibrocartilaginous structures of the knee that function in mechanical load transmission to protect articular cartilage from forces that may initiate osteoarthritic changes. A population of cells responsible for regulating the tissues’ biomechanical properties are meniscus...

Spring 2017

Heffernan, Rachael J

In an effort to contribute to the rich and ongoing conversation on divine anthropomorphism(s), this work examines references to Yhwh’s various body parts in Late Persian/Early Hellenistic period texts of (what is now known in scholarly circles as) the Hebrew Bible from the perspective of social...

Fall 2022

Masoud, Andrew G.

Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...

Fall 2010

Chow, Ava Kalyca

Matrix metalloproteinase‐2 (MMP‐2) was recently revealed to have targets and actions within the cardiac myocyte. In ischemia/reperfusion (I/R) injury, MMP‐2 is activated and degrades troponin I (TnI) and α‐actinin. The regulation of intracellular MMP‐2 activity is relatively unknown and is thus...

Spring 2011

Odenbach, Jeffrey

Angiotensin II signals cardiovascular disease through metalloproteinases including MMP-2, MMP-7 and ADAM-17/TACE. We hypothesized that these metalloproteinases regulate each other at the transcriptional level. Further, MMP-2, being a major gelatinase in cardiac and vascular tissue, could mediate...

Spring 2011

Shearer, Kathleen

Technological advances for treatment of congenital heart disease (CHD) have led to decreases in mortality over the past thirty years. Persistent morbidity into adolescence and adulthood necessitates regular medical follow-up and the influence of ongoing physical health issues on the teens...