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Skip to Search Results- 1Brophy, Taylor Raymond
- 1Buijs, David, M
- 1Cheng Baron, June
- 1Chu, Kevin
- 1Clifford, Alexander M
- 1Collins, Catherine Elizabeth Victoria
- 6Department of Agricultural, Food, and Nutritional Science
- 3Department of Biological Sciences
- 3Department of Medicine
- 2Department of Medical Microbiology and Immunology
- 2Department of Physiology
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Davidge, Sandra T. (Physiology/Obstetrics and Gynecology)
- 1Dr. Andrew Mason (Medicine)
- 1Dr. David Bressler (Agricultural, Food and Nutritional Science)
- 1Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dyck, Jason RB (Pediatrics)/ McAlister, Finlay A (Medicine)
- 1Foley, Edan (Medical Microbiology and Immunology)
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Fall 2023
The calving transition is a challenging period for dairy cows characterized by negative energy balance, metabolic dysfunction, and inflammation, each of which may compromise milk production. Despite extensive research in this area, much is still unknown on how to best manage this period. The...
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Chronic Fatigue Mechanisms in Autoimmune Diseases: Lessons from Primary Biliary Cholangitis and Systemic Sclerosis
DownloadFall 2023
Systemic sclerosis (SSc) is an autoimmune disease affecting the body's connective tissues, resulting in progressive fibrosis and vasculopathy. In some cases, individuals with SSc may also develop primary biliary cholangitis (PBC), another autoimmune disease characterized by damage to their...
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Fall 2022
Background: Although pediatric heart transplantation is a life-saving and effective therapy for children with cardiac disease, barriers remain due to a lack of available organs as well as transplant failure due to rejection. This dissertation aimed to increase knowledge related to immune risk...
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Spring 2022
Dendritic cells (DCs) are antigen presenting cells critical for the initiation of the adaptive immune response. As such, DCs continually circulate the body to survey for foreign antigen in the periphery. DCs encounter a milieu of environmental cues within the traversed microenvironment that can...
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The Effects of Hydraulic Fracturing Flowback and Produced Water on Exercise Capacity and Metabolic Fuel Selection in Rainbow Trout (Oncorhynchus mykiss)
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Hydraulic fracturing is an increasingly popular technique for unconventional hydrocarbon extraction in Canada. As its popularity continues to grow, concerns are being raised regarding its waste product, hydraulic fracturing flowback and produced water (FPW), and its effects on the environment....
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Fall 2020
Eukaryotic cells are characterized by the presence of membrane-bound organelles. Close proximity between organelles has been observed for decades, but only recently we have really started to understand the importance of these contacts for cellular function. These contacts consist of areas of...
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Body Composition Assessment in Pediatric Obesity: Reliability, Validity, and Clinical Applications
DownloadFall 2020
Adipose tissue and skeletal muscle have unique metabolic roles. Despite body mass index for age and sex (BMI z-score) being historically widely used to evaluate and monitor health status in children with obesity, it does not depict adiposity and muscularity (or their changes) during growth or...
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Fall 2020
Interactions between diet, lifespan, metabolism, and immunity are complex but can have profound impact on human health. The Drosophila model is useful to study these interactions as many pathways and processes are highly conserved between flies and humans. In this thesis, I used the defined...
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Myeloperoxidase-mediated bio-activation of NSAIDs in leukemia cells: Potential selective cytotoxicity
DownloadFall 2019
Several lines of evidence have pointed to the potential benefit of anti-inflammatory drugs (NSAIDs) in cancer therapy due to the well-established correlation between cancer and chronic inflammation. Acute myeloid leukemia (AML) cells overexpress myeloperoxidase (MPO), which has been studied for...
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Fall 2019
Parasite aggregation is a population-based metric in which many hosts harbour few parasites but some hosts are infected by a large number of parasites. The causes of aggregation are primarily attributed to heterogeneity in host exposure and susceptibility. However, parasites can exert numerous...