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Skip to Search Results- 1Airo, Adriana M
- 1Berke, Sheldon S
- 1Chahal, Manik
- 1Farhan, Maikel AA
- 1Githaka, John M
- 1Haddad, George
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Fall 2022
Heart transplantation (HTx) is a life-saving intervention for patients with end-stage heart failure. Nonetheless, the development of Chronic Allograft Vasculopathy (CAV) limits the longevity of transplanted cardiac allografts and the survival of recipients. The pathogenesis of CAV begins with a...
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Fall 2020
Despite their small size and apparent simplicity, viruses are capable of causing mass casualties, political turmoil, and global economic shut down. Due to their minimal genome (~10–12 kb), arboviruses such as Zika (ZIKV), Dengue (DENV), and Mayaro (MAYV) depend on many host molecules for...
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Fall 2020
RNA helicases function in all aspects of RNA metabolism, regulating a diverse range of cellular processes by rearranging RNA structures and mediating RNA-protein interactions. Prokaryotic RNA helicases have been shown to have roles in RNA degradation, ribosome biogenesis and translation, with...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Exploiting the Enhanced Permeability and Retention Effect for the Targeting of Tumors with 18F-SiFA Polymer Nanoparticles
DownloadFall 2017
Over the last several decades great progress has been made in cancer diagnosis and detection. One foundation of this progress has been improved imaging technologies. Among the most promising imaging technologies for cancer detection is Positron Emission Tomography (PET). PET imaging allows for...
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Fall 2017
Protein prenylation is the post-translational addition of isoprenoid lipid moieties to proteins, which regulates their subcellular localization and function. Farnesyl or geranylgeranyl isoprenoids are covalently linked to cysteines residues in a C-terminal prenylation recognition sequence in...
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Fall 2017
Epidermal Growth Factor-like domain 7 (EGFL7) is a secreted angiogenic factor that is almost exclusively expressed by endothelial cells. High EGFL7 expression occurs during physiological angiogenesis, under pathological conditions, and in solid tumor angiogenesis. Evidence suggests that EGFL7...
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Fall 2016
Thrombotic microangiopathy (TMA) is a broad term for a range of diseases that usually manifest with rapid failure of the affected organ. Although different in etiology, these diseases share a common pattern of injury originating in the vascular endothelium. In turn, the injured vasculature...
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Plasma Membrane Organization and Endocytosis of CD36 in Human Microvascular Endothelial Cells
DownloadSpring 2016
The plasma membrane is a dynamic lipid bilayer that surrounds the cell, embedded with different plasma membrane proteins, aiding communication between the inside and outside of the cells. Its functions are achieved through an intricate organization of lipid-lipid, lipid-protein and...
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Spring 2014
The introduction of WNV into North America in 1999 was followed by rapid spread throughout the continent. Today, WNV is an endemic pathogen in the west, with thousands of cases of severe infection reported annually. In addition to traditional vaccine research, there is an urgent need to...