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Spring 2011
The lymphocyte function associated antigen-I (LFA-1) is important to a variety of immune cell processes including immune synapse formation and lymphocyte homing. Studies have shown that lymphocytes exhibit increased adhesion upon sialic acid removal by neuraminidase. Recent studies of β1 integrin...
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Spring 2020
The human neuraminidases (NEU1, NEU2, NEU3, and NEU4) are a family of enzymes implicated in pathologies including cancer and diabetes. Our group has developed selective inhibitors for these enzymes that have been employed as tools to understand their biological roles. Several reports have linked...
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Probing the function of LFA-1 using fluorescent proteins that target the beta-2 integrin transmembrane domain
DownloadSpring 2011
The lymphocyte functional antigen-1 (LFA-1) is a type I heterodimeric transmembrane (TM) proteins involved in cell adhesion, and mediates a number of cellular and physiological processes. In this work, we used recombinant fluorescently-tagged proteins derived from the TM domain of the β2 integrin...