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- 7Clostridium
- 7Microbiome
- 6Clostridium difficile
- 5Gastrointestinal Tract
- 3Inflammatory Bowel Disease
- 5Gänzle, Michael G.
- 3Valcheva, Rosica
- 2Armstrong, Glen D.
- 2Dieleman, Levinus
- 2Dieleman, Levinus A.
- 2Dingle, Tanis C.
- 8Graduate and Postdoctoral Studies (GPS), Faculty of
- 8Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 7Agricultural, Food and Nutritional Science, Department of
- 7Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Chemistry, Department of
- 2Chemistry, Department of/Journal Articles (Chemistry)
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Fall 2015
This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) to investigate non-covalent This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) to investigate non-covalent interactions. The first research chapter focuses on the...
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The intestinal microbiota plays a role in Salmonella-induced colitis independent of pathogen colonization
Download2011
Antunes, L. Caetano M., Gill, Navkiran, Russell, Shannon L., Finlay, B. Brett, Ferreira, Rosana B., Croxen, Matthew A., Willing, Benjamin P.
The intestinal microbiota is composed of hundreds of species of bacteria, fungi and protozoa and is critical for numerous biological processes, such as nutrient acquisition, vitamin production, and colonization resistance against bacterial pathogens. We studied the role of the intestinal...
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Spring 2020
There is an increase in the prevalence of inflammatory bowel disease (IBD) worldwide, and this appears to be associated with an increase in the consumption of a Western diet high in fat and sugar, and low in fiber. Previous work shows that two-day exposure to high sugar diets increases the...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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The role of small intestinal permeability in the pathogenesis of colitis in the interleukin-10 gene deficient mouse
DownloadSpring 2011
It is currently believed that the etiology of inflammatory bowel disease involves an aberrant immune response towards the gastrointestinal microbial flora. In addition, an increase in intestinal paracellular permeability may also be a contributing factor of disease, as it precedes disease in...
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Understanding the role of Clostridioides difficile and Vitamin D supplementation in shaping the gut microbiome of Canadian infants
DownloadSpring 2019
Introduction: The gut microbiome is shaped during infancy and has an important role in the development of both the immune and metabolic systems. Many early life exposures and events contribute to the composition of this complex intestinal environment, notably early infant diet and breastfeeding....