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Skip to Search Results- 17Chemotherapy
- 6Clostridium difficile
- 6Glutamine
- 3Breast Cancer
- 3Clostridium
- 3Gastrointestinal Tract
- 4Gänzle, Michael G.
- 3Dieleman, Levinus A.
- 3Field, Catherine J.
- 3Sawyer, Michael B.
- 3Valcheva, Rosica
- 2Armstrong, Glen D.
- 18Graduate and Postdoctoral Studies (GPS), Faculty of
- 18Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 6Agricultural, Food and Nutritional Science, Department of
- 6Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 2Chemistry, Department of
- 2Chemistry, Department of/Journal Articles (Chemistry)
- 3Department of Biochemistry
- 3Faculty of Nursing
- 2Department of Agricultural, Food, and Nutritional Science
- 2Department of Chemistry
- 2Department of Psychiatry
- 2Faculty of Pharmacy and Pharmaceutical Sciences
- 1Baracos, Vickie (Oncology, Agricultural, Food, and Nutritional Science)
- 1Brindley, David N. (University of Alberta, Biochemistry)
- 1Coupland, Nicholas (Psychiatry)
- 1Dr Vera Mazurak, Agricultural, Food and Nutritional Science
- 1Dr. Afsaneh Lavasanifar (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Andrew Belch (Department of Oncology, Faculty of Medicine and Dentistry)
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Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour
Download2009
Xue, Hongyu, Sawyer, Michael B., Le Roy, Severine, Dieleman, Levinus A., Baracos, Vickie E., Field, Catherine J.
Prior reports suggest that during irinotecan (7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin; CPT-11) chemotherapy in laboratory rats, the anti-tumour efficacy and diarrhoea toxicity could be modulated by n-3 PUFA and glutamine, respectively. We further examined how these two...
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Spectral Editing for Detection of Oncologically Relevant Metabolites with In-Vivo Magnetic Resonance Spectroscopy at 9.4 T
DownloadFall 2019
Short echo time (TE) magnetic resonance spectroscopy (MRS) techniques with spectral fitting are commonly employed approaches for brain metabolite quantification at 9.4 T. However, there is a significant overlap of peaks in short-TE spectra, even at 9.4 T. To better resolve resonances, spectral...
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Fall 2015
This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) to investigate non-covalent This thesis describes the application of electrospray ionization mass spectrometry (ESI-MS) to investigate non-covalent interactions. The first research chapter focuses on the...
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Fall 2019
Breast cancer is the leading cause of death among women worldwide. Fortunately, death rates have been declining since 1990, due to the increase in early detection, testing, and improved treatment. However, despite the advancement of targeted and hormone therapies for certain molecular sub-types...
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2013
Ruth, Megan R., Field, Catherine J.
The intestine and the gut-associated lymphoid tissue (GALT) are essential components of whole body immune defense, protecting the body from foreign antigens and pathogens, while allowing tolerance to commensal bacteria and dietary antigens. The requirement for protein to support the immune system...
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The role of intestinal microbiota in development of irinotecan toxicity and in toxicity reduction through dietary fibres in rats
Download2014
Baracos, Vickie, Dieleman, Levinus, Farhangfar, Arazm, Lin, Xiaoxi B., Gänzle, Michael G., Sawyer, Michael B., Valcheva, Rosica, Schieber, Andreas
CPT-11 is a drug used as chemotherapy for colorectal cancer. CPT-11 causes toxic side-effects in patients. CPT-11 toxicity has been attributed to the activity of intestinal microbiota, however, intestinal microbiota may also have protective effects in CP!-11 chemotherapy. This study aimed to...
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Spring 2016
Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...