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Skip to Search Results- 2Kinnaird, Adam
- 1Abdulsalam Alharbi
- 1Akhnokh, Maria Kodsy
- 1Aktary, Zackie M
- 1Alolayan, Waad Riyad
- 1Alshamsan, Aws
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The effect of oral lipids and lipoproteins on the biodistribution, metabolism and electrocardiographic side-effects of halofantrine
DownloadSpring 2011
In the past, hyperlipidemia (HL) has been shown to affect the pharmacokinetic and pharmacodynamic properties of lipophilic drugs extensively bound to lipoproteins, including halofantrine (HF). The present thesis examined the effect of HL on the biodistribution, metabolism and electrocardiographic...
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The Feasibility and Acceptability of a Virtually-Supported Home Exercise Program for People with Multiple Myeloma
DownloadFall 2021
Introduction: Exercise could help alleviate the significant morbidity experienced by people with multiple myeloma (MM). It is unclear if current cancer-specific exercise guidelines are appropriate for this unique population. Supervision, tailoring, and flexibility are proposed as key program...
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The interaction of phenelzine with human monoamine oxidase B: characterization and consequences
DownloadSpring 2022
Phenelzine (PLZ) is a monoamine oxidase (MAO) inhibitor developed in the 1960s which has been used clinically for psychiatric conditions such as depression and anxiety disorders. However, despite over 60 years of research, the mechanism by which PLZ exerts its effects on MAO has yet to be...
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Fall 2014
Chemoresistance is one of the major hurdles to induce a cure in patients with epithelial ovarian cancer (EOC). RUNX3, belonging to the family of RUNX transcription factors, has been shown to act in an oncogenic manner by promoting proliferation and colony formation when overexpressed, in EOC....
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Spring 2015
The tumor suppressor protein Ras association domain family 1A (RASSF1A) has roles in multiple signaling pathways including modulating apoptosis, the cell cycle, DNA damage, and microtubule organization. RASSF1A has been shown to be one of the most frequently epigenetically silenced genes in a...
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Towards superior cancer drugs by modeling approaches: Modification and prediction of the mode of action
DownloadFall 2021
Cancer is a leading cause of death that imposes significant economic and social suffering on a global scale. Based on the projected growth and ageing of populations, the global burden of cancer is set to increase. Despite the vast investment in cancer research, the rate of translation of research...
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Understanding Heart Failure in Patients with Dilated Cardiomyopathy: A Direct Tissue Analysis from Explanted Human Hearts
DownloadFall 2022
Background Chronic heart failure (HF) remains a rising global epidemic that affects both adults and children population. The causes of HF are heterogeneous, and syndromes are often complicated by concomitant disorders such as iron deficiency (ID) and diabetes. Comorbidities not only complicate...
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Unveiling the pathway for the nuclear translocation of the large mitochondrial enzyme Pyruvate Dehydrogenase Complex (PDC)
DownloadSpring 2021
Pyruvate dehydrogenase complex (PDC) is a mitochondrial enzyme that links glycolysis to oxidative phosphorylation by decarboxylating glucose-derived pyruvate to produce acetyl-CoA that is used in the Krebs cycle. PDC was initially thought to reside only in the mitochondrial matrix but we recently...
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Using 1H-NMR based metabolomics to investigate the pathological consequences of mitochondrial disease and human rabies infection
DownloadSpring 2012
Mitochondrial diseases encompass a wide range of clinical phenotypes. The etiology of these disorders is extremely complex; mitochondria are central to energy metabolism and dysfunction can have a profound effect on global metabolism. The original objective of this thesis was to use 1H-NMR based...