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Skip to Search Results- 21Pharmacokinetics
- 7Hepatocytes
- 4Nonsteroidal anti-inflammatory agents
- 3Enantiomers
- 3Pharmacodynamics
- 2Biodistribution
- 1Al Lawati, Hanan M
- 1Anwar-Mohamed, Anwar Gamal Abd El-Naser
- 1Bahitham, Wesam
- 1Bamforth, Fiona
- 1Binkhathlan, Ziyad
- 1Carr, Robert Arthur.
- 24Graduate and Postdoctoral Studies (GPS), Faculty of
- 24Graduate and Postdoctoral Studies (GPS), Faculty of/Theses and Dissertations
- 1Agricultural, Food and Nutritional Science, Department of
- 1Agricultural, Food and Nutritional Science, Department of/Journal Articles (Agricultural, Food and Nutritional Science)
- 1Biological Sciences, Department of
- 1Biological Sciences, Department of/Journal Articles (Biological Sciences)
- 17Faculty of Pharmacy and Pharmaceutical Sciences
- 1Department of Cell Biology
- 1Department of Chemistry
- 1Department of Medical Sciences
- 1Department of Pharmaceutical Sciences
- 1Department of Pharmacology
- 1Brocks, Dion R. (Faculty of Pharmacy and Pharmaceutical Sciences)
- 1Dr. Andrew Holt
- 1Dr. Brocks, Dion R (Faculty of Pharmacy and Pharmaceutical Sciences
- 1Dr. Dion R. Brocks, Faculty of Pharmacy and Pharmaceutical Sciences
- 1El-Kadi, Ayman (Pharmacy and Pharmaceutical Sciences)
- 1Jamali, Fakhreddin ( Pharmacy and Pharmaceutical Science)
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2014
Bamforth, Fiona, Stothard, Paul, Peng, Fred, Sergi, Consolato, Chan, Alicia, Bahitham, Wesam, Stone, Bradley, Mason, Andrew, Liao, Xiaoping
Cholangiocellular carcinoma (CCA) of the liver was the target of more interest, recently, due mainly to its increased incidence and possible association to new environmental factors. Somatic mitochondrial DNA (mtDNA) mutations have been found in several cancers. Some of these malignancies contain...
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MODULATION OF ARYL HYDROCARBON RECEPTOR (AHR)-REGULATED XENOBIOTIC METABOLIZING ENZYMES BY ARSENITE
DownloadFall 2013
Anwar-Mohamed, Anwar Gamal Abd El-Naser
Aryl hydrocarbon receptor (AhR) ligands and heavy metals are environmental co-contaminants and their molecular interaction may disrupt the coordinated regulation of AhR-dependent phase I and II drug metabolizing enzymes. As such, the effect of the heavy metal, As(III), on the AhR-regulated genes...
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Pharmacokinetic interactions of mycophenolic acid: population pharmacokinetics and a translational investigation on p-cresol mediated metabolism interaction
DownloadFall 2022
BackgroundMycophenolic acid (MPA) is a frequently used immunosuppressant after organ transplantation to prevent graft rejection. It is often prescribed concurrently with tacrolimus and corticosteroids. MPA has been associated with significant variations in plasma exposure after kidney...
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Roles of Acyl-CoA:Diacylglycerol Acyltransferases 1 and 2 in Triacylglycerol Synthesis and Secretion in Hepatocytes
DownloadFall 2015
Triacylglycerol (TG) metabolism with its high-energy potential is stringently regulated. Unbalanced TG regulation, either too much TG that overwhelms cellular storage capacity or too little TG due to defects in adipogenesis, is associated with various metabolic disorders. TG can be exported from...
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Spatiotemporal integration of molecular and anatomical data in virtual reality using semantic mapping
Download2009
Janzen, R.P., Dong, X., Gordon, P.M., Soh, J., Wishart, D.S., Sabhaney, A., Turinsky, A.L., Sensen, C.W., Chang, J., Hau, D., Xia, J., Trinh, Q.M.
We have developed a computational framework for spatiotemporal integration of molecular and anatomical datasets in a virtual reality environment. Using two case studies involving gene expression data and pharmacokinetic data, respectively, we demonstrate how existing knowledge bases for molecular...