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Spring 2021

Fahed Elian

The transcription factors FOXC1, FOXQ1, and FOXF2 (FOX cluster on chromosome 6) are members of the forkhead family that play a role in a plethora of biological processes during development and tumorigenesis. Emerging studies in the last decade have suggested a role of the FOX cluster in breast...

Spring 2020

Lewis, Cody Wayne

To ensure faithful cell division, entry into mitosis must be inhibited in cells with damage or under-replicated DNA. Wee1 and Myt1 are two partially redundant kinases that inhibit mitotic entry through the phosphorylation of the Cdk1/cyclin B complex. Cdk1 is an essential mitotic kinase that...

Spring 2012

Buckland, Timothy, W

In Canada, approximately 40% of the population will be diagnosed with cancer and 25% will die of this disease. In order to treat cancer more effectively, new prognostic and therapeutic targets need to be discovered. In breast cancer, the BH3 only protein BAD has been shown to correlate with...

Spring 2016

Bekele, Raie Taye

Tamoxifen is the accepted therapy for patients with estrogen receptor α (ERα)−positive breast cancer. However, clinical resistance to tamoxifen, as demonstrated by recurrence or progression on therapy, is frequent and precedes death from metastases. To improve breast cancer treatment it is vital...

Fall 2016

Chaurasiya, Shyambabu

Breast cancer (BrCa) is the most common cancer and the leading cause of cancer-related deaths in women worldwide. Current therapies for BrCa are insufficient to cure metastatic disease and are often associated with debilitating side effects that severely deteriorate the quality of patients’...