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- 3Vallianatos, H.
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- 2Berry, Tanya R
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DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cells
DownloadSpring 2016
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...
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Developing an M3 Antagonist for Molecular Imaging of Muscarinic Acetylcholine Receptors in Breast Cancer
DownloadFall 2021
The lack of the three targeted receptors, estrogen, progesterone, and the human epidermal growth factor receptor 2, causes difficulty in treating triple negative type cancers. Most often, patients with this type of malignancy have a low chance of survival. The focus of this work will be on...
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Fall 2015
Tumor targeting ligands provide a promising solution to the problems associated with the selective delivery of conventional cancer chemotherapeutics and diagnostics to cancer cells. Therefore, numerous cancer cell surface targeting peptides have been identified and evaluated. These peptides have...
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Establishing the anti-cancer effects of unsaturated fatty acids and a novel oil on human breast cancer cells
DownloadFall 2012
N-3 and n-6 fatty acids and conjugated linoleic (CLA) acid have been known to inhibit breast cancer cell growth, however, effects on normal cells and of single and mixtures of n-3 and n-6 pathway intermediates have not been thoroughly investigated. The objective of this thesis was to determine...
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Fall 2021
Breast cancer is the most common cancer amongst women in Canada. The current treatment regime for early stage breast cancers is breast-conserving surgery with radiation therapy. However, 10-20% of patients develop local recurrence, and some exhibit metastatic spread, which is associated with a...
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2015-10-21
Richter Solina, Ani-Amponsah Mary, Conroy Sherrill
Research Title: Experiences of midwives who are faced with newborns affected by birth asphyxia in rural birth settings, southern Ghana Authors: Ani-Amponsah, Mary*; Richter, Solina; Conroy, Sherrill - University of Alberta Background: Neonatal death rates in low and middle income countries...
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Fall 2015
Background: Breast conserving surgery (BCS) followed by radiation is the preferred treatment option for early stage breast cancer because it is less invasive than the alternative treatment, mastectomy, and provides a better cosmetic outcome and a superior quality of life. Positive surgical...
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Fall 2010
Breast cancer is the most common cancer and the leading cause of cancer-related death among Canadian women. Despite improvements in treatment and early detection, there is still a need to develop novel therapies for breast cancer management. Aberrant Notch signaling is tumorigenic and is...
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Spring 2013
Immigrant women have many emotional, psychological, and/or cultural stressors that may influence their health. For some women, these stressors may only be present during the acculturation process, but for others they may continue throughout the remainder of their lives. Focused ethnography, as...