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Skip to Search Results- 2Veldhoen, Richard
- 1Aburahess, Salah
- 1Akuamoah Boateng, Maxwell
- 1Alqahtani,Hind M
- 1Bekele, Raie Taye
- 1Benesch, Matthew GK
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Spring 2015
Obesity is a national and global issue. Primary care is an important area in the prevention and treatment of obesity. There are numerous potential barriers physicians face in delivering effective practices in obesity management. Identifying major barriers will aid health care systems, medical...
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An Investigation of Integrating Program- and System-level Datasets for Examining Relationships Among Variables of a Complex Health System
DownloadFall 2017
The potential for integrated program- and system-level datasets for generating previously inaccessible evaluative insights remains untapped. This study, situated within a yearlong evaluation of a lifestyle intervention program for patients with metabolic syndrome (MetS), provides an illustrative...
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Anti-Cancer Mechanism of Trastuzumab via Blocking Nuclear HER2 Function and Epigenetic Mechanism of Resistance
DownloadSpring 2020
HER2 receptor tyrosine kinase (encoded by ERBB2 gene) is overexpressed in approximately 25% of all breast cancer tumors (known as HER2-positive breast cancers). Overexpression of HER2 causes overactivation of downstream receptor tyrosine kinase pathways including PI3K/Akt and MAPK pathways and is...
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Association mapping of genes using whole genome polymorphism arrays: Identification of markers of breast cancer susceptibility in Alberta women
DownloadFall 2010
Chakravarthy Sridharan, Malinee
Breast cancer is a heterogeneous, polygenic disease and is influenced by genetic, environmental and life-style factors. Many single nucleotide polymorphisms (SNPs) associated with breast cancer risk have been identified in genome-wide association studies (GWASs) by several research groups for...
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Spring 2015
Autotaxin is a secreted enzyme that produces most of the extracellular lysophosphatidate from lysophosphatidylcholine, the most abundant phospholipid in plasma. Lysophosphatidate mediates many physiological and pathological processes by signaling through six G-protein-coupled receptors to promote...
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Benefits and Challenges of Implementing an Electronic Medical Record System in an Urban Slum in Kenya
DownloadSpring 2016
This Thesis consists of two papers that explore the use of Electronic Medical Record (EMR) systems in resource-limited settings. The first paper (Chapter 2) comprises a State-of-the-Art review of the types of inquiry, settings, interventions and principal findings reported from studies of the...
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Spring 2012
This dissertation explores breast cancer experiences by predominately contemporary American women that are creative interventions into, and re-visions of, experiences in medical and therapeutic environs as well as culturally produced post-surgical bodies. During diagnoses, surgeries and...
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Characterizing physical activity documentation patterns and curriculum of Canadian family physicians
DownloadFall 2022
Family physicians (FP) can be meaningful advocates to support patients to attain the benefits of physical activity (PA); however, the PA-related documentation FPs make in electronic medical records (EMR) is largely unknown. The purpose of this dissertation was to conduct three studies: to examine...
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Common Conditions in Primary Care and Minimal Clinically Important Differences on Depression Scales
DownloadFall 2017
Primary care has the highest patient volume and the greatest complexity of illness compared to other specialties and levels of health care. Although local data are available, a global perspective on the most common reasons for consulting primary care is lacking. Identifying these conditions would...
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DDX17 (P72), a Sox2 binding partner, regulates Sox2 to sustain tumorigenic and stem-like properties in a phenotypically distinct subset of estrogen positive breast cancer cells
DownloadSpring 2016
Abstract: Sox2, an embryonic stem cell marker, is involved in the pathogenesis of breast cancer (BC). Sox2 expression is associated with a poor clinical outcome in BC patients. Based on the differential Sox2 transcriptional activity, we have identified the two phenotypically distinct cell...